Based on: Ovarian Cancer — gene targets, candidate compounds and trials, OSMF Research Tracker (DGIdb, Open Targets, ChEMBL, PubMed and ClinicalTrials.gov data). Numbers are a snapshot taken 8 October 2026; the tracker page is the live version.
Short answer: as of October 2026, the OSMF Research Tracker lists 58 candidate interventions for ovarian Cancer that are either approved medicines or have at least one registered clinical trial, built on 12 druggable gene targets, with 14 recent trials on ClinicalTrials.gov. 2 are already approved medicines, for this condition or another one; where the approval is for a different condition, the trial is testing a new use, which is what drug repurposing means. Being in a trial says an intervention is being studied, not that it works; that is what the trial is for.
Which candidates have the most trial activity?
Ranked by the number of registered trials the tracker found. Each trial ID links to the registry entry, where you can read the design, status and sponsor.
- Carboplatin — 7 registered trials · approved medicine · NCT00214058 NCT00189553 NCT00989651
- Paclitaxel — 7 registered trials · investigational · NCT00189553 NCT00989651 NCT06023862
- Bevacizumab — 5 registered trials · investigational · NCT06307249 NCT01091259 NCT00989651
- Olaparib — 4 registered trials · approved medicine · NCT05887609 NCT04532645 NCT03579316
- Cisplatin — 3 registered trials · investigational · NCT00989651 NCT00003896 NCT00006036
- filgrastim — 3 registered trials · investigational · NCT00004066 NCT00002977 NCT00467051
- Gemcitabine — 3 registered trials · investigational · NCT04616534 NCT06023862 NCT07604766
- Metformin — 3 registered trials · investigational · NCT03792984 NCT00159536 NCT06015594
- 2X-121 — 2 registered trials · investigational · NCT03878849
- Chemotherapy — 2 registered trials · investigational · NCT02728622 NCT07033819
- Docetaxel — 2 registered trials · investigational · NCT00214058 NCT00004066
- Letrozole — 2 registered trials · investigational · NCT06418347 NCT02389088
Which gene targets are these built on?
The tracker starts from genes with evidence of being druggable in ovarian Cancer and asks which compounds act on them. Each symbol links to its DGIdb entry, which lists the interacting drugs and the papers behind them: BRCA1, BRCA2, CCNE1, FOLR1, KDR, MSLN, PARP1, PARP2, PIK3CA, SLC34A2, TP53, VEGFA.
Which trials are registered?
- Predictors of Relapse of Ovarian, Peritoneal, and Fallopian Tube Cancers NCT00086567 · Completed · started 2005-12-12
- A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors NCT07115043 · Recruiting · Phase PHASE1, PHASE2 · started 2025-07-29
- Collection of Blood From Patients With Cancer, Other Tumors, or Tumor Predisposition Syndromes for Genetic Analysis NCT01441089 · Recruiting · started 2012-05-21
- A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer NCT07213804 · Recruiting · Phase PHASE3 · started 2025-10-22
- Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Cancer NCT01174121 · Recruiting · Phase PHASE2 · started 2010-08-26
- NeoVax With Nivolumab in Patients With Ovarian Cancer NCT04024878 · Active Not Recruiting · Phase PHASE1 · started 2020-11-20
- CfDNA in Hereditary And High-risk Malignancies 2 NCT06726642 · Recruiting · started 2024-04-19
- A Study of TRK-950 in Combinations With Anti-Cancer Treatment Regimens in Patients With Advanced Solid Tumors NCT03872947 · Completed · Phase PHASE1 · started 2019-04-26
- Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies NCT04847063 · Recruiting · Phase PHASE1 · started 2021-10-19
- Health-Related Quality of Life and Metabolic Outcomes in PCOS NCT07571915 · Active Not Recruiting · Phase NA · started 2026-06-01
How to read this
Evidence is graded on the tracker page in three tiers: clinical (tested in people), mechanistic (a documented action on the target) and correlative (an association in the literature). Most candidates sit in the lower tiers, and many trials are small or early-phase. The purpose of this list is to show where the research is, with sources, so that patients, clinicians and researchers can look further; it is not a ranking of what to take.
Related on this site
Research information, not medical advice. Decisions about any medicine belong with you and your clinician. The underlying data are open (CC BY 4.0) and refreshed daily; this note was generated from the tracker page on 8 October 2026.