Based on: Cervical Cancer — gene targets, candidate compounds and trials, OSMF Research Tracker (DGIdb, Open Targets, ChEMBL, PubMed and ClinicalTrials.gov data). Numbers are a snapshot taken 8 October 2026; the tracker page is the live version.
Short answer: as of October 2026, the OSMF Research Tracker lists 58 candidate interventions for cervical Cancer that are either approved medicines or have at least one registered clinical trial, built on 10 druggable gene targets, with 14 recent trials on ClinicalTrials.gov. 0 are already approved medicines, for this condition or another one; where the approval is for a different condition, the trial is testing a new use, which is what drug repurposing means. Being in a trial says an intervention is being studied, not that it works; that is what the trial is for.
Which candidates have the most trial activity?
Ranked by the number of registered trials the tracker found. Each trial ID links to the registry entry, where you can read the design, status and sponsor.
- cisplatin — 8 registered trials · investigational · NCT00006248 NCT01088347 NCT00005965
- Pembrolizumab — 6 registered trials · investigational · NCT02432963 NCT05269381 NCT05104567
- Cetuximab — 5 registered trials · investigational · NCT01647555 NCT05104567 NCT02282371
- docetaxel — 4 registered trials · investigational · NCT00003565 NCT00006038 NCT00813072
- fluorouracil — 4 registered trials · investigational · NCT00006248 NCT00006038 NCT05355701
- Radiotherapy — 4 registered trials · investigational · NCT01647555 NCT01262144 NCT00609284
- Carboplatin — 3 registered trials · investigational · NCT07290621 NCT01490749 NCT00498953
- paclitaxel — 3 registered trials · investigational · NCT00006248 NCT00003592 NCT07290621
- quality-of-life assessment — 3 registered trials · investigational · NCT00003321 NCT01155609 NCT01243398
- conventional surgery — 2 registered trials · investigational · NCT00006038 NCT00498953
- Ipilimumab — 2 registered trials · investigational · NCT04080804 NCT03416244
- Irinotecan — 2 registered trials · investigational · NCT00165464 NCT00813072
Which gene targets are these built on?
The tracker starts from genes with evidence of being druggable in cervical Cancer and asks which compounds act on them. Each symbol links to its DGIdb entry, which lists the interacting drugs and the papers behind them: CD274, CDKN2A, EGFR, F3, KDR, PDCD1, PIK3CA, RB1, TP53, VEGFA.
Which trials are registered?
- Biospecimen Procurement for Head and Neck Disorders NCT03429036 · Recruiting · started 2018-05-23
- Renovated Prediction Model for Difficult Transoral and Submental Endoscopic Thyroidectomy NCT06738888 · Recruiting · started 2024-05-01
- A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors NCT07115043 · Recruiting · Phase PHASE1, PHASE2 · started 2025-07-29
- Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer NCT07061977 · Recruiting · Phase PHASE3 · started 2025-11-05
- Comprehensive Evaluation of Tumor Oxygenation, Metabolism and Blood Supply of High Grade Glioma and Cervical Cancers Using Dynamic FAZA PET and Multiparametric MR NCT05047913 · Active Not Recruiting · Phase EARLY_PHASE1 · started 2021-09-20
- Bevonescein for Intra-Operative Nerve Visualization in Head and Neck Surgery NCT05377554 · Completed · Phase PHASE3 · started 2022-04-29
- Oncology, Undernutrition and Sensoriality: Links, Mechanisms and Levers for Action NCT06600295 · Recruiting · started 2024-09-06
- Predictors of Patient-Reported Outcomes for Maxillectomy Patients NCT07864974 · Completed · Phase NA · started 2025-08-12
- Personalized Volume-deescalated Elective Nodal Irradiation in Oropharyngeal Head and Neck Squamous Cell Carcinoma NCT06563362 · Recruiting · Phase PHASE2 · started 2025-02-04
- A Study to Evaluate CRB-701 Compared to Investigator's Choice Therapy in Previously Treated Oropharyngeal Squamous Cell Carcinoma NCT07768189 · Recruiting · Phase PHASE3 · started 2026-09-29
How to read this
Evidence is graded on the tracker page in three tiers: clinical (tested in people), mechanistic (a documented action on the target) and correlative (an association in the literature). Most candidates sit in the lower tiers, and many trials are small or early-phase. The purpose of this list is to show where the research is, with sources, so that patients, clinicians and researchers can look further; it is not a ranking of what to take.
Related on this site
Research information, not medical advice. Decisions about any medicine belong with you and your clinician. The underlying data are open (CC BY 4.0) and refreshed daily; this note was generated from the tracker page on 8 October 2026.