Based on: GERD (Gastroesophageal Reflux Disease) — gene targets, candidate compounds and trials, OSMF Research Tracker (DGIdb, Open Targets, ChEMBL, PubMed and ClinicalTrials.gov data). Numbers are a snapshot taken 8 October 2026; the tracker page is the live version.
Short answer: as of October 2026, the OSMF Research Tracker lists 46 candidate interventions for GERD (Acid Reflux) that are either approved medicines or have at least one registered clinical trial, built on 8 druggable gene targets, with 15 recent trials on ClinicalTrials.gov. 6 are already approved medicines, for this condition or another one; where the approval is for a different condition, the trial is testing a new use, which is what drug repurposing means. Being in a trial says an intervention is being studied, not that it works; that is what the trial is for.
Which candidates have the most trial activity?
Ranked by the number of registered trials the tracker found. Each trial ID links to the registry entry, where you can read the design, status and sponsor.
- Esomeprazole — 4 registered trials · approved medicine · NCT04329000 NCT00317044
- pantoprazole — 3 registered trials · approved medicine · NCT00362609 NCT00307944 NCT01887743
- Dexlansoprazole — 2 registered trials · approved medicine · NCT02616302 NCT00627016
- Lansoprazole — 2 registered trials · approved medicine · NCT01990339 NCT01135368
- Vonoprazan — 2 registered trials · approved medicine · NCT05366738
- Esomeprazole 40 mg — 2 registered trials · investigational · NCT04568772 NCT04329000
- Omeprazole — 1 registered trial · approved medicine · NCT00256737
- Aciphex — 1 registered trial · investigational · NCT00204698
- AG1321001(drug) — 1 registered trial · investigational · NCT00380315
- Alginate-antacid group — 1 registered trial · investigational · NCT03516188
- Atovaquone / Proguanil 250/100 mg — 1 registered trial · investigational · NCT04568772
- AZD3355 — 1 registered trial · investigational · NCT00757419
Which gene targets are these built on?
The tracker starts from genes with evidence of being druggable in GERD (Acid Reflux) and asks which compounds act on them. Each symbol links to its DGIdb entry, which lists the interacting drugs and the papers behind them: ATP4A, CHRM3, CLDN1, HRH2, IL8, PTGS2, TJP1, TRPV1.
Which trials are registered?
- Evaluation of the Fundoplicature of the Excluded Stomach Post Omega Bypass NCT06621979 · Recruiting · Phase NA · started 2025-11-24
- An Observational Study to Evaluate the Efficacy and Safety of K-CAB Tab./K-CAB ODT(Tegoprazan) in GERD Patients NCT07678177 · Recruiting · started 2023-03-07
- A Study in Patients With Erosive Esophagitis to Investigate Safety, Tolerability, and Healing Rates After 4 Weeks Treatment of X842 or Lansoprazole and Symptom Pattern During Subsequent 4 Weeks Treatment With Lansoprazole NCT05055128 · Completed · Phase PHASE2 · started 2021-08-11
- Redo Surgery or Transcatheter Valve-in-Valve for Mitral Bioprosthetic Dysfunction (SURViV) NCT04402931 · Completed · Phase NA · started 2020-02-17
- Transpyloric Versus Gastric Feeding in Bronchopulmonary Dysplasia NCT06534359 · Recruiting · Phase NA · started 2025-07-15
- Randomized Controlled Crossover Trial of Postpyloric Feedings to Improve Pulmonary Outcomes in High-risk Preterm Infants NCT05777512 · Recruiting · Phase NA · started 2024-04-26
- Esophagogastric Junction Distensibility During Hiatal Hernia Repair NCT04450628 · Active Not Recruiting · Phase NA · started 2020-09-28
- Safety and Effectiveness of eGERD Device to Reduce Gastroesophageal Reflux Disease (GERD) Symptoms NCT06613438 · Recruiting · Phase NA · started 2024-09-15
- Abbott Cephea Mitral Valve Disease Registry NCT07069673 · Recruiting · started 2025-08-13
- Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of X842 in Human: A Single/Multiple Ascending Dose Study NCT03105375 · Completed · Phase EARLY_PHASE1 · started 2017-02-21
How to read this
Evidence is graded on the tracker page in three tiers: clinical (tested in people), mechanistic (a documented action on the target) and correlative (an association in the literature). Most candidates sit in the lower tiers, and many trials are small or early-phase. The purpose of this list is to show where the research is, with sources, so that patients, clinicians and researchers can look further; it is not a ranking of what to take.
Related on this site
Research information, not medical advice. Decisions about any medicine belong with you and your clinician. The underlying data are open (CC BY 4.0) and refreshed daily; this note was generated from the tracker page on 8 October 2026.