Based on: Gastroparesis — gene targets, candidate compounds and trials, OSMF Research Tracker (DGIdb, Open Targets, ChEMBL, PubMed and ClinicalTrials.gov data). Numbers are a snapshot taken 8 October 2026; the tracker page is the live version.
Short answer: as of October 2026, the OSMF Research Tracker lists 47 candidate interventions for gastroparesis that are either approved medicines or have at least one registered clinical trial, built on 9 druggable gene targets, with 14 recent trials on ClinicalTrials.gov. 0 are already approved medicines, for this condition or another one; where the approval is for a different condition, the trial is testing a new use, which is what drug repurposing means. Being in a trial says an intervention is being studied, not that it works; that is what the trial is for.
Which candidates have the most trial activity?
Ranked by the number of registered trials the tracker found. Each trial ID links to the registry entry, where you can read the design, status and sponsor.
- Gastric emptying of carbohydrate-rich beverage — 3 registered trials · investigational · NCT02753010
- Domperidone — 2 registered trials · investigational · NCT01696734 NCT04699591
- Erythromycin — 2 registered trials · investigational · NCT01659619 NCT02005029
- GSK962040 (50 mg) — 2 registered trials · investigational · NCT01039805 NCT00861809
- Pancreaticoduodenectomy — 2 registered trials · investigational · NCT02246205 NCT06413888
- TAK-906 Maleate — 2 registered trials · investigational · NCT03544229 NCT03268941
- 13C-uracil — 1 registered trial · investigational · NCT01677338
- 99mTc sulfur colloid — 1 registered trial · investigational · NCT01677338
- A — 1 registered trial · investigational · NCT01267071
- Aprepitant — 1 registered trial · investigational · NCT01149369
- Atmo gas capsule — 1 registered trial · investigational · NCT04977063
- B — 1 registered trial · investigational · NCT01267071
Which gene targets are these built on?
The tracker starts from genes with evidence of being druggable in gastroparesis and asks which compounds act on them. Each symbol links to its DGIdb entry, which lists the interacting drugs and the papers behind them: CNR1, DRD2, GHSR, HTR3A, HTR4, KIT, MLNR, NOS1, TACR1.
Which trials are registered?
- To Study the Efficacy and Safety of Medtronic 780G Insulin Pump in People With Gastroparesis and Type 1 Diabetes. NCT07287943 · Recruiting · Phase NA · started 2026-02-09
- Different Doses of Naronapride vs. Placebo in Gastroparesis NCT05621811 · Completed · Phase PHASE2 · started 2023-01-03
- Effect of Gastric Electrical Stimulation on Serum Insulin Levels NCT07635576 · Recruiting · Phase NA · started 2026-07-23
- Cardiac Vagal Effects of GES in Patients With Gastroparesis and Vagal Nerve Action Potentials in Vagus Nerve NCT02159586 · Completed · started 2012-11-01
- Gastric Focused Ultrasound Stimulation NCT07851727 · Recruiting · Phase NA · started 2026-09-11
- Vagus Nerve Response in Gastroparesis Patients NCT04207996 · Completed · started 2019-09-01
- Effect of Itopride on Semaglutide Gastroparesis NCT07254715 · Completed · Phase PHASE4 · started 2026-01-01
- Domperidone in Treating Patients With Gastrointestinal Disorders NCT01696734 · Active Not Recruiting · Phase PHASE3 · started 2012-10-23
- Evaluating the Safety and Efficacy of Tradipitant vs. Placebo in Idiopathic and Diabetic Gastroparesis NCT04028492 · Completed · Phase PHASE3 · started 2019-08-20
- Gastric Ultrasound for Estimation of the Aspiration Risk Study NCT03310528 · Completed · started 2018-03-27
How to read this
Evidence is graded on the tracker page in three tiers: clinical (tested in people), mechanistic (a documented action on the target) and correlative (an association in the literature). Most candidates sit in the lower tiers, and many trials are small or early-phase. The purpose of this list is to show where the research is, with sources, so that patients, clinicians and researchers can look further; it is not a ranking of what to take.
Related on this site
Research information, not medical advice. Decisions about any medicine belong with you and your clinician. The underlying data are open (CC BY 4.0) and refreshed daily; this note was generated from the tracker page on 8 October 2026.