Based on: Chronic Pancreatitis — gene targets, candidate compounds and trials, OSMF Research Tracker (DGIdb, Open Targets, ChEMBL, PubMed and ClinicalTrials.gov data). Numbers are a snapshot taken 8 October 2026; the tracker page is the live version.
Short answer: as of October 2026, the OSMF Research Tracker lists 58 candidate interventions for chronic Pancreatitis that are either approved medicines or have at least one registered clinical trial, built on 10 druggable gene targets, with 14 recent trials on ClinicalTrials.gov. 0 are already approved medicines, for this condition or another one; where the approval is for a different condition, the trial is testing a new use, which is what drug repurposing means. Being in a trial says an intervention is being studied, not that it works; that is what the trial is for.
Which candidates have the most trial activity?
Ranked by the number of registered trials the tracker found. Each trial ID links to the registry entry, where you can read the design, status and sponsor.
- Cholecalciferol — 2 registered trials · investigational · NCT01141998
- computed tomography — 2 registered trials · investigational · NCT06549725 NCT06699667
- Creon — 2 registered trials · investigational · NCT00957151 NCT01154608
- Lactated ringers solution — 2 registered trials · investigational · NCT05772234 NCT07202559
- Mesenchymal stem cells — 2 registered trials · investigational · NCT05925036 NCT06205342
- normal saline — 2 registered trials · investigational · NCT05772234 NCT07202559
- Quantitative Sensory Test 1 — 2 registered trials · investigational · NCT04996628 NCT03434392
- Quantitative Sensory Test 2 — 2 registered trials · investigational · NCT04996628 NCT03434392
- Quantitative Sensory Test 3 — 2 registered trials · investigational · NCT04996628 NCT03434392
- triamcinolone — 2 registered trials · investigational · NCT00583271 NCT00658736
- 98% dehydrated alcohol — 1 registered trial · investigational · NCT00583271
- Alpha 1-Antitrypsin — 1 registered trial · investigational · NCT02713997
Which gene targets are these built on?
The tracker starts from genes with evidence of being druggable in chronic Pancreatitis and asks which compounds act on them. Each symbol links to its DGIdb entry, which lists the interacting drugs and the papers behind them: CFTR, CPA1, CTRC, OPRM1, PDGFRB, PRSS1, SCN9A, SPINK1, TGFB1, TRPV1.
Which trials are registered?
- Inebilizumab for the Treatment of Patients With Type 1 Autoimmune Pancreatitis NCT07862075 · Recruiting · Phase PHASE4 · started 2025-10-01
- A Trial on the Remission Rates of Type I Autoimmune Pancreatits With High-risk of Recurrence NCT06468709 · Recruiting · Phase PHASE4 · started 2024-06-30
- Metabolic Impact of Pancreatic Duct Decompression NCT07810309 · Recruiting · Phase PHASE1 · started 2026-09-30
- Safety and Efficacy of Mesenchymal Stem Cells Associated With Chronic Pancreatitis Pain NCT06205342 · Recruiting · Phase EARLY_PHASE1 · started 2024-07-17
- Scrambler Therapy in Chronic Pancreatitis NCT07174609 · Recruiting · Phase NA · started 2024-11-01
- The Natural History of Chronic Pancreatitis NCT03324698 · Active Not Recruiting · started 2000-01-01
- Endotherapy and/or Extracorporeal Shockwave Lithotripsy for Painless Chronic Pancreatitis NCT07074379 · Recruiting · Phase NA · started 2025-07-21
- The Pancreas Interception Center (PIC) for Early Detection, Prevention, and Novel Therapeutics NCT05692596 · Active Not Recruiting · started 2022-10-06
- Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis NCT04996628 · Recruiting · Phase NA · started 2022-01-04
- QST Study: Predicting Treatment Response in Chronic Pancreatitis Using Quantitative Sensory Testing NCT03434392 · Recruiting · Phase NA · started 2017-10-24
How to read this
Evidence is graded on the tracker page in three tiers: clinical (tested in people), mechanistic (a documented action on the target) and correlative (an association in the literature). Most candidates sit in the lower tiers, and many trials are small or early-phase. The purpose of this list is to show where the research is, with sources, so that patients, clinicians and researchers can look further; it is not a ranking of what to take.
Related on this site
Research information, not medical advice. Decisions about any medicine belong with you and your clinician. The underlying data are open (CC BY 4.0) and refreshed daily; this note was generated from the tracker page on 8 October 2026.