Based on: Heart Failure — gene targets, candidate compounds and trials, OSMF Research Tracker (DGIdb, Open Targets, ChEMBL, PubMed and ClinicalTrials.gov data). Numbers are a snapshot taken 8 October 2026; the tracker page is the live version.
Short answer: as of October 2026, the OSMF Research Tracker lists 52 candidate interventions for heart Failure that are either approved medicines or have at least one registered clinical trial, built on 9 druggable gene targets, with 14 recent trials on ClinicalTrials.gov. 1 are already approved medicines, for this condition or another one; where the approval is for a different condition, the trial is testing a new use, which is what drug repurposing means. Being in a trial says an intervention is being studied, not that it works; that is what the trial is for.
Which candidates have the most trial activity?
Ranked by the number of registered trials the tracker found. Each trial ID links to the registry entry, where you can read the design, status and sponsor.
- CK-1827452 — 3 registered trials · investigational · NCT00941681
- Cardiac Resynchronization Therapy — 2 registered trials · investigational · NCT03723265 NCT01577446
- Insulin — 2 registered trials · investigational · NCT01565941
- Sacubitril/Valsartan — 2 registered trials · investigational · NCT05243199 NCT05096039
- Eplerenone — 1 registered trial · approved medicine · NCT01955694
- 6 minute walk test (6MWT) — 1 registered trial · investigational · NCT05887271
- Accelerometery — 1 registered trial · investigational · NCT05887271
- Angiotensin II type 1 receptor antagonists — 1 registered trial · investigational · NCT00001628
- Azathioprine — 1 registered trial · investigational · NCT04654988
- BAY94-8862 — 1 registered trial · investigational · NCT01955694
- Blood test — 1 registered trial · investigational · NCT05887271
- Candesartan — 1 registered trial · investigational · NCT00634400
Which gene targets are these built on?
The tracker starts from genes with evidence of being druggable in heart Failure and asks which compounds act on them. Each symbol links to its DGIdb entry, which lists the interacting drugs and the papers behind them: ACE, ADRB1, ADRB2, AGTR1, MME, MYH7, NPR1, NR3C2, SLC5A2.
Which trials are registered?
- Prospective Evaluation of AI-ECG for SHD Detection NCT07057466 · Recruiting · started 2025-11-04
- Impact of a Cardiac Rehabilitation Program on Patients With Cardiac Amyloidosis NCT07494942 · Recruiting · Phase NA · started 2026-09-23
- The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes) NCT06383390 · Active Not Recruiting · Phase PHASE3 · started 2024-04-30
- Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258) NCT06898515 · Recruiting · Phase PHASE3 · started 2025-07-14
- A Study to Learn About the Use of Acoramidis in Patients With a Heart Condition Called Transthyretin Amyloid Cardiomyopathy (ATTR-CM) in a Real-world Setting NCT07235462 · Recruiting · started 2025-10-29
- The RENAL LIFECYCLE Trial: A RCT to Assess the Effect of Dapagliflozin on Renal and Cardiovascular Outcomes in Patients With Severe CKD NCT05374291 · Active Not Recruiting · Phase PHASE3 · started 2022-11-08
- High-Sensitivity Troponin T Plasma Levels in Patients With Aortic Stenosis (Tyrolean Aortic Stenosis Study-2) NCT02448485 · Completed · started 2015-06
- Intestinal Microbiota Transplantation in Patients With Chronic Heart Failure NCT07490054 · Recruiting · Phase PHASE1 · started 2025-10-20
- Advanced Respiratory Monitoring and Oxygen Therapy in Chronically Ill Patients With Acute Respiratory Failure NCT07157696 · Recruiting · Phase NA · started 2025-11-05
- Synchronized Diaphragmatic Stimulation in Symptomatic Heart Failure NCT06552637 · Recruiting · Phase NA · started 2026-07-08
How to read this
Evidence is graded on the tracker page in three tiers: clinical (tested in people), mechanistic (a documented action on the target) and correlative (an association in the literature). Most candidates sit in the lower tiers, and many trials are small or early-phase. The purpose of this list is to show where the research is, with sources, so that patients, clinicians and researchers can look further; it is not a ranking of what to take.
Related on this site
Research information, not medical advice. Decisions about any medicine belong with you and your clinician. The underlying data are open (CC BY 4.0) and refreshed daily; this note was generated from the tracker page on 8 October 2026.