Based on: Fibromyalgia — gene targets, candidate compounds and trials, OSMF Research Tracker (DGIdb, Open Targets, ChEMBL, PubMed and ClinicalTrials.gov data). Numbers are a snapshot taken 8 October 2026; the tracker page is the live version.
Short answer: as of October 2026, the OSMF Research Tracker lists 43 candidate interventions for fibromyalgia that are either approved medicines or have at least one registered clinical trial, built on 6 druggable gene targets, with 14 recent trials on ClinicalTrials.gov. 1 are already approved medicines, for this condition or another one; where the approval is for a different condition, the trial is testing a new use, which is what drug repurposing means. Being in a trial says an intervention is being studied, not that it works; that is what the trial is for.
Which candidates have the most trial activity?
Ranked by the number of registered trials the tracker found. Each trial ID links to the registry entry, where you can read the design, status and sponsor.
- pregabalin — 2 registered trials · approved medicine · NCT00151489 NCT00883740
- Dry needling — 2 registered trials · investigational · NCT05320601 NCT06023836
- Esreboxetine — 2 registered trials · investigational · NCT00752505
- milnacipran — 2 registered trials · investigational · NCT01173055 NCT01234675
- Pregabalin capsule — 2 registered trials · investigational · NCT07708948 NCT03890133
- A Peltier for Sensory testing — 1 registered trial · investigational · NCT03075254
- ABM — 1 registered trial · investigational · NCT05905159
- Acetaminophen — 1 registered trial · investigational · NCT00766675
- Acupuncture — 1 registered trial · investigational · NCT01270607
- AXS-14 (Esreboxetine) — 1 registered trial · investigational · NCT07398417
- Botulinum Toxin A Injection — 1 registered trial · investigational · NCT06899438
- Breathing and Attention Training (BAT) — 1 registered trial · investigational · NCT05773482
Which gene targets are these built on?
The tracker starts from genes with evidence of being druggable in fibromyalgia and asks which compounds act on them. Each symbol links to its DGIdb entry, which lists the interacting drugs and the papers behind them: GRIN1, GRIN2B, SCN9A, SLC6A2, SLC6A4, TRPV1.
Which trials are registered?
- Combination of Pregabalin and Trigger Point Injection With Ropivacaine in the Treatment of Myofascial Pain Syndrome of the Neck and Upper Back. NCT07866443 · Completed · Phase PHASE4 · started 2025-03-01
- Psychologically Informed Telerehabilitation for Fibromyalgia NCT07865403 · Recruiting · Phase NA · started 2026-09-01
- Melatonin and Immunonutrition for Pain Relief in Fibromyalgia NCT07863232 · Recruiting · Phase NA · started 2026-10
- Effect of Vagus Nerve Stimulation on Trapezius Trigger Point NCT07045324 · Completed · Phase NA · started 2025-01-15
- Self-regulation of Real-time fMRI Brain Activity in Chronic Pain NCT07023523 · Recruiting · Phase NA · started 2025-10-31
- Fatigue in Primary Sjögren's Syndrome NCT04802577 · Completed · started 2021-01-04
- Dietary Strategies for the Treatment of Fibromyalgia in Overweight and Obese Patients NCT07517757 · Recruiting · Phase NA · started 2026-04-10
- Explosive Synchronization of Brain Network Activity in Chronic Pain NCT04606095 · Active Not Recruiting · Phase NA · started 2020-11-13
- Effect of Virtual Reality Combined With Balance Training on Biodex Balance System in Female With Fibromyalgia NCT07004101 · Active Not Recruiting · Phase NA · started 2025-04-15
- Shiatsu for Chronic Non-Inflammatory Pain in Children and Adolescents NCT06929598 · Recruiting · Phase NA · started 2025-05-01
How to read this
Evidence is graded on the tracker page in three tiers: clinical (tested in people), mechanistic (a documented action on the target) and correlative (an association in the literature). Most candidates sit in the lower tiers, and many trials are small or early-phase. The purpose of this list is to show where the research is, with sources, so that patients, clinicians and researchers can look further; it is not a ranking of what to take.
Related on this site
Research information, not medical advice. Decisions about any medicine belong with you and your clinician. The underlying data are open (CC BY 4.0) and refreshed daily; this note was generated from the tracker page on 8 October 2026.