Based on: Alzheimer's Disease and Other Dementias — gene targets, candidate compounds and trials, OSMF Research Tracker (DGIdb, Open Targets, ChEMBL, PubMed and ClinicalTrials.gov data). Numbers are a snapshot taken 8 October 2026; the tracker page is the live version.
Short answer: as of October 2026, the OSMF Research Tracker lists 45 candidate interventions for Alzheimer's disease that are either approved medicines or have at least one registered clinical trial, built on 10 druggable gene targets, with 14 recent trials on ClinicalTrials.gov. 0 are already approved medicines, for this condition or another one; where the approval is for a different condition, the trial is testing a new use, which is what drug repurposing means. Being in a trial says an intervention is being studied, not that it works; that is what the trial is for.
Which candidates have the most trial activity?
Ranked by the number of registered trials the tracker found. Each trial ID links to the registry entry, where you can read the design, status and sponsor.
- risperidone — 6 registered trials · investigational · NCT00417482 NCT00208819 NCT00034762
- Olanzapine — 3 registered trials · investigational · NCT00015548 NCT00245206 NCT00208819
- active tDCS — 2 registered trials · investigational · NCT05478681 NCT05730023
- KarXT — 2 registered trials · investigational · NCT06585787 NCT06947941
- ML-007C-MA — 2 registered trials · investigational · NCT07459660 NCT06887192
- Quetiapine — 2 registered trials · investigational · NCT00015548 NCT00208819
- Active tDCS paired with active online chair yoga — 1 registered trial · investigational · NCT07303998
- Algorithm — 1 registered trial · investigational · NCT05779839
- Aripiprazole — 1 registered trial · investigational · NCT00245206
- BI 409306 25 mg — 1 registered trial · investigational · NCT02392468
- BI 409306 50 mg — 1 registered trial · investigational · NCT02392468
- blood sample taken — 1 registered trial · investigational · NCT04946916
Which gene targets are these built on?
The tracker starts from genes with evidence of being druggable in Alzheimer's disease and asks which compounds act on them. Each symbol links to its DGIdb entry, which lists the interacting drugs and the papers behind them: ACHE, APOE, APP, BACE1, BCHE, CHRNA7, GRIN1, MAPT, PSEN1, TREM2.
Which trials are registered?
- InRAD Observational Study NCT07213700 · Recruiting · started 2026-03-30
- A Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Alzheimer's Disease Psychosis NCT06887192 · Recruiting · Phase PHASE2 · started 2025-08-15
- A Study to Assess the Efficacy and Safety of ITI-1284 in the Treatment of Psychosis Associated With Alzheimer's Disease NCT06540833 · Recruiting · Phase PHASE2 · started 2024-08-15
- A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4) NCT06585787 · Recruiting · Phase PHASE3 · started 2024-09-26
- A Research Study Looking at the Effect of Semaglutide on the Immune System and Other Biological Processes in People With Alzheimer's Disease NCT05891496 · Completed · Phase PHASE3 · started 2023-06-20
- Establishing Normal Cognitive Test Scores for Adults Using a Voice-Enabled Digital Testing Platform Across the Lifespan NCT07763392 · Recruiting · started 2026-03-23
- Digital Dementia Registry Bavaria (digiDEM Bayern): a Multicentre, Prospective, Longitudinal Register Study Including People With Mild Cognitive Impairment and Dementia as Well as Their Family Caregivers NCT07721701 · Recruiting · started 2020-08-10
- A Study to Evaluate Safety and Efficacy of KarXT + KarX-EC as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-5) NCT06947941 · Recruiting · Phase PHASE3 · started 2026-03-25
- Stress and Blood Pressure Management for Caregivers NCT05734638 · Active Not Recruiting · Phase NA · started 2023-09-11
- Changing Talk Online Training (CHATO) National Trial NCT04610944 · Completed · Phase NA · started 2021-04-26
How to read this
Evidence is graded on the tracker page in three tiers: clinical (tested in people), mechanistic (a documented action on the target) and correlative (an association in the literature). Most candidates sit in the lower tiers, and many trials are small or early-phase. The purpose of this list is to show where the research is, with sources, so that patients, clinicians and researchers can look further; it is not a ranking of what to take.
Related on this site
Research information, not medical advice. Decisions about any medicine belong with you and your clinician. The underlying data are open (CC BY 4.0) and refreshed daily; this note was generated from the tracker page on 8 October 2026.