Peer-Reviewed Literature Synthesis

Post-Acute COVID-19 Vaccination Syndrome Biomarker Atlas

Molecular, serologic, immunologic, and functional alterations reported in Post-Acute COVID-19 Vaccination Syndrome (PACVS) — persistent symptoms following SARS-CoV-2 vaccination — from PACVS/PCVS primary studies and post-vaccination adverse-event literature.

Literature Overview

Biomarkers below are included only where peer-reviewed literature explicitly reports the marker's direction in Post-Acute COVID-19 Vaccination Syndrome patients relative to a named comparison population — not inferred.

32
Curated markers
8
Categories

Searchable Alterations Database

Comparison populations are quoted as reported in the source literature (e.g. healthy controls, disease-matched patients).

Marker / TestDirectionCategoryvs. ComparisonClinical ContextKey Reference

Key References

Peer-Reviewed Literature

Patterson et al. 2025

DOI: 10.1080/21645515.2025.2494934 →
Peer-Reviewed Literature

Yonker et al. 2023

DOI: 10.1161/CIRCULATIONAHA.122.061725 →
Peer-Reviewed Literature

Sano et al. 2025

DOI: 10.1016/j.jdermsci.2025.09.007 →
Peer-Reviewed Literature

Ota et al. 2025

DOI: 10.1016/j.jocn.2025.111223 →
Peer-Reviewed Literature

Federico 2024

DOI: 10.3390/vaccines12111281 →
Peer-Reviewed Literature

Sutton et al. 2023

DOI: 10.1016/j.vaccine.2023.04.044 →
Peer-Reviewed Literature

Camperi et al. 2025

DOI: 10.3390/molecules30071629 →
Peer-Reviewed Literature

Mantovani et al. 2024

DOI: 10.3390/biomedicines12122852 →
Peer-Reviewed Literature

Mundorf et al. 2024

DOI: 10.3390/vaccines12070790 →
Peer-Reviewed Literature

Halma & Varon 2025

DOI: 10.1016/j.biopha.2025.118864 →
Peer-Reviewed Literature

Halma 2024

DOI: 10.2196/preprints.70342 →
Disclaimer: Educational synthesis of peer-reviewed literature only — not medical advice. Markers are drawn from published disease-vs-comparison-population studies; inclusion here does not imply diagnostic or clinical validation. Consult a qualified healthcare professional for interpretation.

Part of the Open Source Medicine Foundation Network

Open Source Medicine Foundation The OSMF hub — advancing open-source biomedical research infrastructure, tools, and evidence synthesis.
SpikeProtein.site Database and research resource on SARS-CoV-2 spike protein biology, persistence, and clinical implications.
Vaccine Data Navigator Open-access navigation tool for vaccine adverse event reporting and surveillance data.
VitalScan4PACVS Remote physiological monitoring study for post-acute COVID-19 vaccination syndrome.
PACVS Research Summit Annual summit convening researchers, clinicians, and patients on PACVS science.