Peer-Reviewed Literature Synthesis

Myalgic Encephalomyelitis / Chronic Fatigue Syndrome Biomarker Atlas

Molecular, metabolic, immunological, and autonomic alterations in myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) compared to healthy sedentary and active controls — including post-exertional malaise (PEM) phenotypes.

Literature Overview

Biomarkers below are included only where peer-reviewed literature explicitly reports the marker's direction in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome patients relative to a named comparison population — not inferred.

46
Curated markers
9
Categories

Searchable Alterations Database

Comparison populations are quoted as reported in the source literature (e.g. healthy controls, disease-matched patients).

Marker / TestDirectionCategoryvs. ComparisonClinical ContextKey Reference

Key References

Peer-Reviewed Literature

Corbitt et al. 2019

DOI: 10.1016/j.psyneuen.2019.05.008 →
Peer-Reviewed Literature

Strawbridge et al. 2019

DOI: 10.1016/j.psyneuen.2019.06.019 →
Peer-Reviewed Literature

Jinushi et al. 2023

DOI: 10.1186/s12967-023-04347-4 →
Peer-Reviewed Literature

Holden et al. 2020

DOI: 10.1186/s12967-020-02477-4 →
Peer-Reviewed Literature

Saito et al. 2024

DOI: 10.3389/fimmu.2024.1341843 →
Peer-Reviewed Literature

Maksoud et al. 2023

DOI: 10.1186/s12916-023-02893-9 →
Peer-Reviewed Literature

Nelson et al. 2019

DOI: 10.1186/s12967-019-02100-4 →
Peer-Reviewed Literature

Taccori et al. 2023

DOI: 10.1186/s12967-023-04398-7 →
Disclaimer: Educational synthesis of peer-reviewed literature only — not medical advice. Markers are drawn from published disease-vs-comparison-population studies; inclusion here does not imply diagnostic or clinical validation. Consult a qualified healthcare professional for interpretation.

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