Remission & chronicity
Spontaneous remission
Annual mortality ~22% on standard care; only 5-11% of HFrEF patients achieve normalisation of ejection fraction (HFrecEF) with GDMT; HFpEF has no disease-modifying therapy
Best-intervention remission
GDMT (ARNI + beta-blocker + MRA + SGLT2i) reduces CV mortality by 38% and hospitalization by 25% vs historical standard; reverse cardiac remodelling (EF improvement >10%) in 40-50% of HFrEF with full quadruple therapy; cardiac resynchronisation therapy (CRT) improves EF in 70% of LBBB patients
Gap size
Large — quadruple GDMT dramatically underused; <25% of eligible HFrEF patients receive all four pillars
Primary barrier
practice/access
Biomarker Targets & Therapeutic Agents
Gene targets queried against DGIdb, Open Targets, ChEMBL, PubMed, and Europe PMC. Agents ranked: ● Clinical > ● Mechanistic > ● Correlative.
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| SALVIANOLIC ACID B | ? unclear | Mechanistic | DGIdb | |
| CANDOXATRIL | ? unclear | Mechanistic | DGIdb | |
| CILAZAPRIL | ↓ inhibits | Mechanistic | DGIdb | |
| TP0556351 | ↓ inhibits | Mechanistic | DGIdb | |
| PRAVASTATIN SODIUM | ? unclear | Mechanistic | DGIdb | |
| SILDENAFIL | ? unclear | Mechanistic | DGIdb | |
| GEMFIBROZIL | ? unclear | Mechanistic | DGIdb | |
| RESCINNAMINE | ? unclear | Mechanistic | DGIdb | |
| SPIRAPRIL | ? unclear | Mechanistic | DGIdb | |
| INDOMETHACIN | ? unclear | Mechanistic | DGIdb | |
| HYDROCHLOROTHIAZIDE | ? unclear | Mechanistic | DGIdb | |
| ARGIPRESSIN | ? unclear | Mechanistic | DGIdb | |
| METOPROLOL | ? unclear | Mechanistic | DGIdb | |
| DELAPRIL | ↓ inhibits | Mechanistic | DGIdb | |
| ACETYLCHOLINE | ? unclear | Mechanistic | DGIdb | |
| THERAPEUTIC GLUCOCORTICOID | ? unclear | Mechanistic | DGIdb | |
| IMIDAPRIL | ↓ inhibits | Mechanistic | DGIdb | |
| MALATHION | ↓ inhibits | Mechanistic | DGIdb | |
| MOEXIPRIL | ? unclear | Mechanistic | 56.0 nM (IC50) | DGIdb |
| VORINOSTAT | ? unclear | Mechanistic | DGIdb | |
| ILEPATRIL | ↓ inhibits | Mechanistic | DGIdb | |
| RXP470.1 | ↓ inhibits | Mechanistic | DGIdb | |
| CGS-27023A | ? unclear | Mechanistic | DGIdb | |
| NITROPRUSSIDE | ? unclear | Mechanistic | DGIdb | |
| ENALAPRILAT ANHYDROUS | ↓ inhibits | Mechanistic | 1.2 nM (IC50) | DGIdb |
| TORSEMIDE | ? unclear | Mechanistic | DGIdb | |
| ATORVASTATIN CALCIUM TRIHYDRATE | ? unclear | Mechanistic | DGIdb | |
| FOSINOPRIL | ? unclear | Mechanistic | DGIdb | |
| FUROSEMIDE | ? unclear | Mechanistic | DGIdb | |
| TEMOCAPRIL HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| BENAZEPRIL HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| CARBARIL | ↓ inhibits | Mechanistic | DGIdb | |
| BUPROPION HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| QUINAPRIL | ? unclear | Mechanistic | 8.3 nM (IC50) | DGIdb |
| COMPOUND 1 [PMID: 24900526] | ↓ inhibits | Mechanistic | DGIdb | |
| COMPOUND 20 [PMID: 22153340] | ↓ inhibits | Mechanistic | DGIdb | |
| BUMETANIDE | ? unclear | Mechanistic | DGIdb | |
| GALLOPAMIL | ? unclear | Mechanistic | DGIdb | |
| FLUOXETINE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| AZD6605 | ↓ inhibits | Mechanistic | DGIdb |
Showing top 40 of 229 agents ranked by evidence tier.
ADRB1
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| BRETYLIUM | ? unclear | Mechanistic | DGIdb | |
| PINDOLOL | ↑ activates | Mechanistic | DGIdb | |
| BISOPROLOL | ? unclear | Mechanistic | DGIdb | |
| FLECAINIDE ACETATE | ? unclear | Mechanistic | DGIdb | |
| METIPRANOLOL | ? unclear | Mechanistic | DGIdb | |
| METOPROLOL | ? unclear | Mechanistic | DGIdb | |
| ATENOLOL | ↓ inhibits | Mechanistic | DGIdb | |
| BUCINDOLOL HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| METIPRANOLOL HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| ALPRENOLOL | ? unclear | Mechanistic | 4.88 nM (IC50) | DGIdb |
| PRACTOLOL | ↓ inhibits | Mechanistic | DGIdb | |
| XAMOTEROL | ↑ activates | Mechanistic | DGIdb | |
| PENBUTOLOL | ? unclear | Mechanistic | DGIdb | |
| DOBUTAMINE | ? unclear | Mechanistic | DGIdb | |
| BETHANIDINE | ? unclear | Mechanistic | DGIdb | |
| BETAXOLOL | ? unclear | Mechanistic | 37.1 nM (IC50) | DGIdb |
| MURAGLITAZAR | ? unclear | Mechanistic | DGIdb | |
| ACEBUTOLOL | ? unclear | Mechanistic | DGIdb | |
| LABETALOL HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| ACEBUTOLOL HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| NOREPINEPHRINE | ? unclear | Mechanistic | DGIdb | |
| OT-730 | ? unclear | Mechanistic | DGIdb | |
| CARVEDILOL | ↓ inhibits | Mechanistic | DGIdb | |
| NADOLOL | ↓ inhibits | Mechanistic | DGIdb | |
| LEVOBUNOLOL | ↓ inhibits | Mechanistic | DGIdb | |
| LABETALOL | ? unclear | Mechanistic | DGIdb | |
| TERTATOLOL | ? unclear | Mechanistic | DGIdb | |
| ARBUTAMINE | ? unclear | Mechanistic | DGIdb | |
| PROPRANOLOL HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| ZIPRASIDONE | ? unclear | Mechanistic | DGIdb | |
| BUPRANOLOL | ? unclear | Mechanistic | DGIdb | |
| LANDIOLOL | ↓ inhibits | Mechanistic | DGIdb | |
| OXPRENOLOL | ? unclear | Mechanistic | DGIdb | |
| MEPINDOLOL | ? unclear | Mechanistic | DGIdb | |
| CELIPROLOL | ↓ inhibits | Mechanistic | DGIdb | |
| BISOPROLOL FUMARATE | ↓ inhibits | Mechanistic | DGIdb | |
| DESIPRAMINE | ? unclear | Mechanistic | DGIdb | |
| DOPAMINE | ↑ activates | Mechanistic | DGIdb | |
| ISOPROTERENOL | ↑ activates | Mechanistic | DGIdb | |
| DOBUTAMINE HYDROCHLORIDE | ↑ activates | Mechanistic | DGIdb |
Showing top 40 of 288 agents ranked by evidence tier.
ADRB2
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| CARVEDILOL | ↓ inhibits | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL1257092 | ? unclear | Mechanistic | DGIdb | |
| SODIUM CHLORIDE | ? unclear | Mechanistic | DGIdb | |
| PENBUTOLOL SULFATE | ↓ inhibits | Mechanistic | DGIdb | |
| DESIPRAMINE | ? unclear | Mechanistic | DGIdb | |
| METIPRANOLOL | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL531322 | ? unclear | Mechanistic | DGIdb | |
| NADOLOL | ↓ inhibits | Mechanistic | DGIdb | |
| PIRBUTEROL | ? unclear | Mechanistic | DGIdb | |
| FENOTEROL | ↑ activates | Mechanistic | DGIdb | |
| TIMOLOL | ↓ inhibits | Mechanistic | DGIdb | |
| ABEDITEROL | ↑ activates | Mechanistic | DGIdb | |
| PINDOLOL | ↑ activates | Mechanistic | DGIdb | |
| BRONCHODILATOR | ? unclear | Mechanistic | DGIdb | |
| TULOBUTEROL | ↑ activates | Mechanistic | DGIdb | |
| PHENYLEPHRINE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| GSK159802 | ↑ activates | Mechanistic | DGIdb | |
| PRILOCAINE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| CLENBUTEROL | ↑ activates | Mechanistic | DGIdb | |
| PROPRANOLOL HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| INDACATEROL MALEATE | ↑ activates | Mechanistic | DGIdb | |
| VILANTEROL | ? unclear | Mechanistic | DGIdb | |
| TERTATOLOL | ? unclear | Mechanistic | DGIdb | |
| ARFORMOTEROL | ↑ activates | Mechanistic | DGIdb | |
| INDACATEROL | ? unclear | Mechanistic | DGIdb | |
| FORMOTEROL FUMARATE | ↑ activates | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL111201 | ? unclear | Mechanistic | DGIdb | |
| RITODRINE | ? unclear | Mechanistic | DGIdb | |
| RISPERIDONE | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL599896 | ? unclear | Mechanistic | DGIdb | |
| VILANTEROL TRIFENATATE | ↑ activates | Mechanistic | DGIdb | |
| RITODRINE HYDROCHLORIDE | ↑ activates | Mechanistic | DGIdb | |
| DISULFIRAM | ? unclear | Mechanistic | DGIdb | |
| BUCINDOLOL HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| LEVALBUTEROL TARTRATE | ↑ activates | Mechanistic | DGIdb | |
| LAS190792 | ↑ activates | Mechanistic | DGIdb | |
| ALPRENOLOL | ? unclear | Mechanistic | DGIdb | |
| CELIPROLOL | ↑ activates | Mechanistic | DGIdb | |
| ALBUTEROL SULFATE | ↑ activates | Mechanistic | DGIdb | |
| CARTEOLOL | ? unclear | Mechanistic | DGIdb |
Showing top 40 of 335 agents ranked by evidence tier.
AGTR1
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| CANDESARTAN CILEXETIL | ↓ inhibits | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL586135 | ? unclear | Mechanistic | DGIdb | |
| VALSARTAN | ↓ inhibits | Mechanistic | 4700.0 nM (Ki) | DGIdb |
| EPROSARTAN MESYLATE | ↓ inhibits | Mechanistic | DGIdb | |
| FIMASARTAN | ↓ inhibits | Mechanistic | DGIdb | |
| ASCORBIC ACID | ? unclear | Mechanistic | DGIdb | |
| OLMESARTAN MEDOXOMIL | ↓ inhibits | Mechanistic | DGIdb | |
| AZILSARTAN MEDOXOMIL | ↓ inhibits | Mechanistic | DGIdb | |
| THERAPEUTIC ANDROSTANOLONE | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL347610 | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL421088 | ? unclear | Mechanistic | DGIdb | |
| LOSARTAN POTASSIUM | ↓ inhibits | Mechanistic | 5.5 nM (IC50) | DGIdb |
| CHEMBL:CHEMBL1492017 | ? unclear | Mechanistic | DGIdb | |
| SPARSENTAN | ↓ inhibits | Mechanistic | DGIdb | |
| SODIUM CHLORIDE | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL261693 | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL1972216 | ? unclear | Mechanistic | DGIdb | |
| EPROSARTAN | ? unclear | Mechanistic | 7.3 nM (IC50) | DGIdb |
| C-FOS ANTISENSE | ? unclear | Mechanistic | DGIdb | |
| SARALASIN ACETATE | ↓ inhibits | Mechanistic | DGIdb | |
| IRBESARTAN | ↓ inhibits | Mechanistic | 1.1 nM (Ki) | DGIdb |
| DISULFIRAM | ? unclear | Mechanistic | DGIdb | |
| SAPRISARTAN | ? unclear | Mechanistic | DGIdb | |
| H2O2 | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL591834 | ? unclear | Mechanistic | DGIdb | |
| CAPTOPRIL | ? unclear | Mechanistic | DGIdb | |
| ANGIOTENSIN II | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL400912 | ? unclear | Mechanistic | DGIdb | |
| ATORVASTATIN CALCIUM TRIHYDRATE | ? unclear | Mechanistic | DGIdb | |
| IDOXIFENE | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL528694 | ? unclear | Mechanistic | DGIdb | |
| IL-6 | ? unclear | Mechanistic | DGIdb | |
| ANGIOTENSIN II ACETATE | ↑ activates | Mechanistic | DGIdb | |
| LEVODOPA | ? unclear | Mechanistic | DGIdb | |
| GAMMA-INTERFERON | ? unclear | Mechanistic | DGIdb | |
| AZILSARTAN KAMEDOXOMIL | ↓ inhibits | Mechanistic | DGIdb | |
| HYDROCHLOROTHIAZIDE | ? unclear | Mechanistic | DGIdb | |
| CHEMBL:CHEMBL1445650 | ? unclear | Mechanistic | DGIdb | |
| MUSCLE RELAXANT | ? unclear | Mechanistic | DGIdb | |
| CL-329167 | ? unclear | Mechanistic | DGIdb |
Showing top 40 of 249 agents ranked by evidence tier.
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| SLV-334 | ? unclear | Mechanistic | DGIdb | |
| RACECADOTRIL | ↓ inhibits | Mechanistic | DGIdb | |
| PL37 | ? unclear | Mechanistic | DGIdb | |
| SACUBITRIL/VALSARTAN | ? unclear | Mechanistic | DGIdb | |
| CANDOXATRIL | ? unclear | Mechanistic | DGIdb | |
| PEPINEMAB | ? unclear | Mechanistic | DGIdb | |
| ILEPATRIL | ↓ inhibits | Mechanistic | DGIdb | |
| GALLOPAMIL | ? unclear | Mechanistic | DGIdb | |
| DAGLUTRIL | ↓ inhibits | Mechanistic | DGIdb | |
| SACUBITRIL | ↓ inhibits | Mechanistic | DGIdb | |
| SAMPATRILAT | ? unclear | Mechanistic | DGIdb | |
| CGS-314447 | ↓ inhibits | Mechanistic | 6.9 nM (IC50) | ChEMBL |
| (R)-THIORPHAN | ↓ inhibits | Mechanistic | 1.7 nM (Ki) | ChEMBL |
| CHEMBL418704 | ↓ inhibits | Mechanistic | 17.0 nM (IC50) | ChEMBL |
| CHEMBL10251 | ↓ inhibits | Mechanistic | 4.8 nM (IC50) | ChEMBL |
| CHEMBL9963 | ↓ inhibits | Mechanistic | 8.8 nM (IC50) | ChEMBL |
| CHEMBL276690 | ↓ inhibits | Mechanistic | 0.7 nM (IC50) | ChEMBL |
| CHEMBL273489 | ↓ inhibits | Mechanistic | 2.5 nM (IC50) | ChEMBL |
| CHEMBL268473 | ↓ inhibits | Mechanistic | 0.6 nM (IC50) | ChEMBL |
| THIORPHAN | ↓ inhibits | Mechanistic | 4.7 nM (Ki) | ChEMBL |
| CHEMBL81232 | ↓ inhibits | Mechanistic | 4.9 nM (Ki) | ChEMBL |
| CHEMBL312460 | ↓ inhibits | Mechanistic | 408.0 nM (Ki) | ChEMBL |
| CHEMBL268761 | ↓ inhibits | Mechanistic | 1.46 nM (IC50) | ChEMBL |
| CHEMBL81710 | ↓ inhibits | Mechanistic | 162.0 nM (Ki) | ChEMBL |
| (S)-THIORPHAN | ↓ inhibits | Mechanistic | 2.2 nM (Ki) | ChEMBL |
| PHOSPHORAMIDON | ↓ inhibits | Mechanistic | 30.0 nM (IC50) | ChEMBL |
| CHEMBL290698 | ↓ inhibits | Mechanistic | 0.9 nM (IC50) | ChEMBL |
| CHEMBL276872 | ↓ inhibits | Mechanistic | 0.74 nM (IC50) | ChEMBL |
| CHEMBL39812 | ↓ inhibits | Mechanistic | 26000.0 nM (IC50) | ChEMBL |
| CHEMBL37052 | ↓ inhibits | Mechanistic | 250.0 nM (IC50) | ChEMBL |
| CHEMBL273748 | ↓ inhibits | Mechanistic | 1.3 nM (IC50) | ChEMBL |
| CHEMBL273898 | ↓ inhibits | Mechanistic | 3.5 nM (IC50) | ChEMBL |
| CHEMBL290256 | ↓ inhibits | Mechanistic | 8600.0 nM (IC50) | ChEMBL |
| CHEMBL289150 | ↓ inhibits | Mechanistic | 6700.0 nM (IC50) | ChEMBL |
| CHEMBL147847 | ↓ inhibits | Mechanistic | 5800.0 nM (IC50) | ChEMBL |
| CHEMBL448098 | ↓ inhibits | Mechanistic | 11000.0 nM (IC50) | ChEMBL |
| CHEMBL37861 | ↓ inhibits | Mechanistic | 55000.0 nM (IC50) | ChEMBL |
| CHEMBL290332 | ↓ inhibits | Mechanistic | 640.0 nM (IC50) | ChEMBL |
| CHEMBL290868 | ↓ inhibits | Mechanistic | 6200.0 nM (IC50) | ChEMBL |
| CHEMBL276008 | ↓ inhibits | Mechanistic | 3.5 nM (IC50) | ChEMBL |
Showing top 40 of 184 agents ranked by evidence tier.
MYH7
NPR1
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| CARPERITIDE | ↑ activates | Mechanistic | 0.1 nM (EC50) | DGIdb |
| NITROPRUSSIDE | ? unclear | Mechanistic | DGIdb | |
| NESIRITIDE | ↑ activates | Mechanistic | DGIdb | |
| ERYTHRITYL TETRANITRATE | ? unclear | Mechanistic | DGIdb | |
| ATRIAL NATRIURETIC PEPTIDE | ? unclear | Mechanistic | DGIdb | |
| PL-3994 | ↑ activates | Mechanistic | DGIdb | |
| NITRIC OXIDE | ? unclear | Mechanistic | DGIdb | |
| CENDERITIDE | ? unclear | Mechanistic | DGIdb | |
| ISOSORBIDE DINITRATE | ? unclear | Mechanistic | DGIdb | |
| ATACIGUAT | ? unclear | Mechanistic | DGIdb | |
| NITROGLYCERIN | ? unclear | Mechanistic | DGIdb | |
| ULARITIDE | ? unclear | Mechanistic | DGIdb | |
| ISOSORBIDE MONONITRATE | ? unclear | Mechanistic | DGIdb | |
| CHEMBL402664 | ↑ activates | Mechanistic | 215.24 nM (EC50) | ChEMBL |
| CHEMBL405572 | ↑ activates | Mechanistic | 4.94 nM (EC50) | ChEMBL |
| MiniANP | ↑ activates | Mechanistic | 0.68 nM (EC50) | ChEMBL |
| CHEMBL384862 | ↑ activates | Mechanistic | 8.28 nM (EC50) | ChEMBL |
| CHEMBL409400 | ↑ activates | Mechanistic | 46.74 nM (EC50) | ChEMBL |
| CHEMBL439465 | ↑ activates | Mechanistic | 30.11 nM (EC50) | ChEMBL |
| CHEMBL414517 | ↑ activates | Mechanistic | 65.85 nM (EC50) | ChEMBL |
| CHEMBL385216 | ↑ activates | Mechanistic | 176.99 nM (EC50) | ChEMBL |
| CHEMBL413653 | ↑ activates | Mechanistic | 107.95 nM (EC50) | ChEMBL |
| CHEMBL408343 | ↑ activates | Mechanistic | 198.41 nM (EC50) | ChEMBL |
| CHEMBL294263 | ↓ inhibits | Mechanistic | 0.3 nM (Ki) | ChEMBL |
| CHEMBL405854 | ↓ inhibits | Mechanistic | 0.65 nM (Ki) | ChEMBL |
| CHEMBL415133 | ↓ inhibits | Mechanistic | 87.0 nM (Ki) | ChEMBL |
| CHEMBL412793 | ↓ inhibits | Mechanistic | 360.0 nM (Ki) | ChEMBL |
| CHEMBL294262 | ↓ inhibits | Mechanistic | 680.0 nM (Ki) | ChEMBL |
| CHEMBL434023 | ↓ inhibits | Mechanistic | 2600.0 nM (Ki) | ChEMBL |
| CHEMBL61413 | ↓ inhibits | Mechanistic | 2900.0 nM (Ki) | ChEMBL |
| CHEMBL59028 | ↓ inhibits | Mechanistic | 62.0 nM (Ki) | ChEMBL |
| CHEMBL304191 | ↓ inhibits | Mechanistic | 65.0 nM (Ki) | ChEMBL |
| CHEMBL264744 | ↓ inhibits | Mechanistic | 0.49 nM (Ki) | ChEMBL |
| CHEMBL435181 | ↓ inhibits | Mechanistic | 539.0 nM (Ki) | ChEMBL |
| CHEMBL61383 | ↓ inhibits | Mechanistic | 0.4 nM (Ki) | ChEMBL |
| CHEMBL411542 | ↓ inhibits | Mechanistic | 0.1 nM (Ki) | ChEMBL |
| CHEMBL507122 | ↓ inhibits | Mechanistic | 36.0 nM (IC50) | ChEMBL |
| CHEMBL1643388 | ↓ inhibits | Mechanistic | 6.0 nM (IC50) | ChEMBL |
| CHEMBL1643389 | ↓ inhibits | Mechanistic | 60.0 nM (IC50) | ChEMBL |
| CHEMBL1643390 | ↓ inhibits | Mechanistic | 240.0 nM (IC50) | ChEMBL |
Showing top 40 of 104 agents ranked by evidence tier.
NR3C2
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| SPIRONOLACTONE | ↓ inhibits | Mechanistic | 2.323 nM (Ki) | DGIdb |
| EPLERENONE | ↓ inhibits | Mechanistic | DGIdb | |
| CORTICOSTERONE | ↑ activates | Mechanistic | DGIdb | |
| DROSPIRENONE | ↓ inhibits | Mechanistic | DGIdb | |
| BENZODROCORTISONE | ↑ activates | Mechanistic | DGIdb | |
| NIMODIPINE | ↓ inhibits | Mechanistic | DGIdb | |
| FLUDROCORTISONE ACETATE | ↑ activates | Mechanistic | DGIdb | |
| VAMOROLONE | ↓ inhibits | Mechanistic | DGIdb | |
| BUDESONIDE | ↑ activates | Mechanistic | DGIdb | |
| DESOXYCORTICOSTERONE | ↑ activates | Mechanistic | DGIdb | |
| DESOXYCORTICOSTERONE ACETATE | ↑ activates | Mechanistic | DGIdb | |
| LY-2623091 | ? unclear | Mechanistic | DGIdb | |
| ESAXERENONE | ↓ inhibits | Mechanistic | DGIdb | |
| APARARENONE | ↓ inhibits | Mechanistic | DGIdb | |
| AZD-9977 | ↓ inhibits | Mechanistic | DGIdb | |
| FLUDROCORTISONE | ↑ activates | Mechanistic | DGIdb | |
| CANRENONE | ↓ inhibits | Mechanistic | DGIdb | |
| HYDROCORTISONE BUTYRATE | ↑ activates | Mechanistic | DGIdb | |
| CANRENOATE POTASSIUM | ↓ inhibits | Mechanistic | DGIdb | |
| FELODIPINE | ↓ inhibits | Mechanistic | DGIdb | |
| AZD9567 | ↑ activates | Mechanistic | DGIdb | |
| BALCINRENONE | ~ modulates | Mechanistic | DGIdb | |
| DEXAMETHASONE | ↑ activates | Mechanistic | 33.0 nM (IC50) | DGIdb |
| RU28318 | ↓ inhibits | Mechanistic | DGIdb | |
| XL550 | ↓ inhibits | Mechanistic | DGIdb | |
| ONAPRISTONE | ↓ inhibits | Mechanistic | 470.0 nM (IC50) | DGIdb |
| FLUTICASONE | ↑ activates | Mechanistic | DGIdb | |
| ZK112993 | ↓ inhibits | Mechanistic | DGIdb | |
| PROGESTERONE | ↓ inhibits | Mechanistic | 14.0 nM (IC50) | DGIdb |
| ALDOSTERONE | ↑ activates | Mechanistic | DGIdb | |
| PF-03882845 | ↓ inhibits | Mechanistic | DGIdb | |
| DESOXYCORTICOSTERONE PIVALATE | ↑ activates | Mechanistic | DGIdb | |
| FINERENONE | ↓ inhibits | Mechanistic | DGIdb | |
| LY2623091 | ↓ inhibits | Mechanistic | DGIdb | |
| PREDNISOLONE | ↑ activates | Mechanistic | 37.0 nM (Ki) | DGIdb |
| OCEDURENONE | ↓ inhibits | Mechanistic | DGIdb | |
| MT-3995 | ? unclear | Mechanistic | Open Targets | |
| CHEMBL134277 | ↓ inhibits | Mechanistic | 1900.0 nM (IC50) | ChEMBL |
| CHEMBL415524 | ↓ inhibits | Mechanistic | 334.0 nM (IC50) | ChEMBL |
| MEDROXYPROGESTERONE ACETATE | ↓ inhibits | Mechanistic | 1197.0 nM (IC50) | ChEMBL |
Showing top 40 of 213 agents ranked by evidence tier.
SLC5A2
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| TOFOGLIFLOZIN | ↓ inhibits | Mechanistic | DGIdb | |
| SERGLIFLOZIN ETABONATE | ↓ inhibits | Mechanistic | DGIdb | |
| IPRAGLIFLOZIN | ↓ inhibits | Mechanistic | DGIdb | |
| LICOGLIFLOZIN | ↓ inhibits | Mechanistic | DGIdb | |
| HENAGLIFLOZIN | ↓ inhibits | Mechanistic | DGIdb | |
| YM-543 | ↓ inhibits | Mechanistic | DGIdb | |
| GLUFOSFAMIDE | ? unclear | Mechanistic | DGIdb | |
| DAPAGLIFLOZIN PROPANEDIOL | ↓ inhibits | Mechanistic | DGIdb | |
| IPRAGLIFLOZIN L-PROLINE | ↓ inhibits | Mechanistic | DGIdb | |
| REMOGLIFLOZIN ETABONATE | ↓ inhibits | Mechanistic | DGIdb | |
| ERTUGLIFLOZIN PIDOLATE | ↓ inhibits | Mechanistic | DGIdb | |
| EMPAGLIFLOZIN | ↓ inhibits | Mechanistic | DGIdb | |
| ERTUGLIFLOZIN | ↓ inhibits | Mechanistic | DGIdb | |
| SOTAGLIFLOZIN | ↓ inhibits | Mechanistic | DGIdb | |
| CANAGLIFLOZIN | ↓ inhibits | Mechanistic | DGIdb | |
| BEXAGLIFLOZIN | ↓ inhibits | Mechanistic | DGIdb | |
| TOFOGLIFLOZIN ANHYDROUS | ? unclear | Mechanistic | Open Targets | |
| DAPAGLIFLOZIN | ? unclear | Mechanistic | 1.1 nM (EC50) | Open Targets |
| CHEMBL183937 | ↓ inhibits | Mechanistic | 4.0 nM (Ki) | ChEMBL |
| CHEMBL187805 | ↓ inhibits | Mechanistic | 10.0 nM (Ki) | ChEMBL |
| CHEMBL187163 | ↓ inhibits | Mechanistic | 9.0 nM (Ki) | ChEMBL |
| CHEMBL187749 | ↓ inhibits | Mechanistic | 10.0 nM (Ki) | ChEMBL |
| CHEMBL184530 | ↓ inhibits | Mechanistic | 230.0 nM (Ki) | ChEMBL |
| CHEMBL184027 | ↓ inhibits | Mechanistic | 70.0 nM (Ki) | ChEMBL |
| CHEMBL188013 | ↓ inhibits | Mechanistic | 40.0 nM (Ki) | ChEMBL |
| CHEMBL361672 | ↓ inhibits | Mechanistic | 520.0 nM (Ki) | ChEMBL |
| CHEMBL187056 | ↓ inhibits | Mechanistic | 290.0 nM (Ki) | ChEMBL |
| CHEMBL360824 | ↓ inhibits | Mechanistic | 1280.0 nM (Ki) | ChEMBL |
| CHEMBL184364 | ↓ inhibits | Mechanistic | 10.0 nM (Ki) | ChEMBL |
| CHEMBL359962 | ↓ inhibits | Mechanistic | 10.0 nM (Ki) | ChEMBL |
| CHEMBL184183 | ↓ inhibits | Mechanistic | 30.0 nM (Ki) | ChEMBL |
| CHEMBL183790 | ↓ inhibits | Mechanistic | 150.0 nM (Ki) | ChEMBL |
| CHEMBL365222 | ↓ inhibits | Mechanistic | 20.0 nM (Ki) | ChEMBL |
| CHEMBL187686 | ↓ inhibits | Mechanistic | 110.0 nM (Ki) | ChEMBL |
| CHEMBL186823 | ↓ inhibits | Mechanistic | 30.0 nM (Ki) | ChEMBL |
| CHEMBL187060 | ↓ inhibits | Mechanistic | 20.0 nM (Ki) | ChEMBL |
| CHEMBL362365 | ↓ inhibits | Mechanistic | 80.0 nM (Ki) | ChEMBL |
| CHEMBL183689 | ↓ inhibits | Mechanistic | 70.0 nM (Ki) | ChEMBL |
| CHEMBL371448 | ↓ inhibits | Mechanistic | 491.0 nM (IC50) | ChEMBL |
| CHEMBL382302 | ↓ inhibits | Mechanistic | 458.0 nM (IC50) | ChEMBL |
Showing top 40 of 190 agents ranked by evidence tier.
Clinical Trials
Recruiting and recently completed trials from ClinicalTrials.gov. Data retrieved 2026-07-06.
No recent clinical trials found on ClinicalTrials.gov for this condition.
Agents Found By Disease-Level Search
Searched directly from “Heart Failure” via ClinicalTrials.gov interventions and Open Targets' disease→drug data — independent of the 9-gene target panel above. This surfaces agents whose mechanism doesn't route through a curated gene (combination therapies, standard-of-care drugs, targets outside the panel).
Not yet run. python -m biomarker_pipeline.run_disease_agent_discovery --disease "..."