Biomarker & Intervention Discovery

Anxiety Disorders

Pharmacologically actionable gene targets, therapeutic agents ranked by evidence tier, and active clinical trials.

Disease Overview

Spontaneous remission
Not established
Best-intervention remission
Gap size
Primary barrier
Biomarker Targets & Therapeutic Agents

Gene targets queried against DGIdb, Open Targets, ChEMBL, PubMed, and Europe PMC. Agents ranked: ● Clinical > ● Mechanistic > ● Correlative.

BDNF 126CRH 9GABRA1 303GABRA2 237HTR1A 260SLC6A2 269SLC6A4 224
Therapeutic Agent Effect Direction Evidence Tier Potency Source
TRAMADOL ? unclear Mechanistic
FLUTICASONE activates Mechanistic
IONOMYCIN ? unclear Mechanistic
MONOAMINE OXIDASE INHIBITOR ? unclear Mechanistic
FREUND'S ADJUVANT ? unclear Mechanistic
LITHIUM ? unclear Mechanistic
ZINC SULFATE ANHYDROUS ? unclear Mechanistic
CAPSAICIN ? unclear Mechanistic
PROPRANOLOL HYDROCHLORIDE ? unclear Mechanistic
MARIJUANA ? unclear Mechanistic
NORTRIPTYLINE ? unclear Mechanistic
BORTEZOMIB ? unclear Mechanistic
GLUCAGON (RDNA) ? unclear Mechanistic
COLCHICINE ? unclear Mechanistic
DOXEPIN HYDROCHLORIDE ? unclear Mechanistic
DRONABINOL ? unclear Mechanistic
TANAPROGET activates Mechanistic
CYCLOOXYGENASE INHIBITOR ? unclear Mechanistic
VERTEPORFIN ? unclear Mechanistic
ANTIOXIDANT ? unclear Mechanistic
DITIOCARB ? unclear Mechanistic
APR19 inhibits Mechanistic
DOXORUBICIN HYDROCHLORIDE ? unclear Mechanistic
OPIATE ? unclear Mechanistic
OXIDOPAMINE ? unclear Mechanistic
TETRADECANOYLPHORBOL ACETATE ? unclear Mechanistic
INSULIN, REGULAR, HUMAN ? unclear Mechanistic
PROPYLTHIOURACIL ? unclear Mechanistic
TROGLITAZONE ? unclear Mechanistic
TYROSINE HYDROXYLASE INHIBITOR ? unclear Mechanistic
ALTEPLASE ? unclear Mechanistic
MEDICATION ? unclear Mechanistic
HALOPERIDOL DECANOATE ? unclear Mechanistic
ASOPRISNIL inhibits Mechanistic
ANALGESIC AGENT ? unclear Mechanistic
TCDD ? unclear Mechanistic
THERAPEUTIC GONADOTROPIN ? unclear Mechanistic
METHADONE HYDROCHLORIDE ? unclear Mechanistic
RECOMBINANT TRANSFORMING GROWTH FACTOR ? unclear Mechanistic
ONAPRISTONE inhibits Mechanistic

Showing top 40 of 126 agents ranked by evidence tier.

Therapeutic Agent Effect Direction Evidence Tier Potency Source
ROSIGLITAZONE ? unclear Mechanistic
ACIVICIN inhibits Mechanistic
MEDICATION ? unclear Mechanistic
GGSTOP inhibits Mechanistic
ANTIDEPRESSANT AGENT ? unclear Mechanistic
IRX-2 ? unclear Mechanistic
ANTISERUM ? unclear Mechanistic
NALOXONE HYDROCHLORIDE ? unclear Mechanistic
CHEMBL5286255 inhibits Mechanistic 0.7 nM (Ki)
Therapeutic Agent Effect Direction Evidence Tier Potency Source
CHLORDIAZEPOXIDE ~ modulates Mechanistic
ETIFOXINE inhibits Mechanistic
DIAZEPAM ~ modulates Mechanistic 36.0 nM (Kd)
METHARBITAL ~ modulates Mechanistic
L838417 ~ modulates Mechanistic
GANAXOLONE ~ modulates Mechanistic
THIAMYLAL SODIUM ~ modulates Mechanistic
EVT 201 ? unclear Mechanistic
ADINAZOLAM ? unclear Mechanistic
ZK-93423 ? unclear Mechanistic
AMOBARBITAL ? unclear Mechanistic
ETHCHLORVYNOL ~ modulates Mechanistic
SECOBARBITAL SODIUM ~ modulates Mechanistic
MEPHOBARBITAL ? unclear Mechanistic
ZOLPIDEM TARTRATE ~ modulates Mechanistic
METHAQUALONE ~ modulates Mechanistic
TOPIRAMATE ~ modulates Mechanistic
PAGOCLONE ~ modulates Mechanistic
THIOCOLCHICOSIDE ? unclear Mechanistic
[3H]AZIETOMIDATE ? unclear Mechanistic
PENTOBARBITAL SODIUM ~ modulates Mechanistic
MIDAZOLAM HYDROCHLORIDE ~ modulates Mechanistic
TRIAZOLAM ~ modulates Mechanistic 1.0 nM (Kd)
BARBITURATE ? unclear Mechanistic
LORAZEPAM ~ modulates Mechanistic
BUTOBARBITAL ? unclear Mechanistic
TETRAHYDRODEOXYCORTICOSTERONE ~ modulates Mechanistic
CLOTIAZEPAM ~ modulates Mechanistic
MEPROBAMATE activates Mechanistic
[3H]CGS8216 ~ modulates Mechanistic
PROPOFOL ~ modulates Mechanistic
CLOBAZAM ~ modulates Mechanistic
SEVOFLURANE ~ modulates Mechanistic
METHOXYFLURANE ~ modulates Mechanistic
LOREDIPLON ~ modulates Mechanistic
CIPEPOFOL activates Mechanistic
INDIPLON ~ modulates Mechanistic
PHENOBARBITAL ? unclear Mechanistic
PRAZEPAM ~ modulates Mechanistic
CLORAZEPATE ? unclear Mechanistic

Showing top 40 of 303 agents ranked by evidence tier.

Therapeutic Agent Effect Direction Evidence Tier Potency Source
METHARBITAL ~ modulates Mechanistic
OCINAPLON ? unclear Mechanistic
THIOPENTAL ? unclear Mechanistic
DIAZEPAM ~ modulates Mechanistic 17.0 nM (Ki)
PENTOBARBITAL SODIUM ~ modulates Mechanistic
FLUDIAZEPAM ? unclear Mechanistic
ADINAZOLAM ? unclear Mechanistic
ADIPIPLON activates Mechanistic
TOPIRAMATE ~ modulates Mechanistic
CLORAZEPATE DIPOTASSIUM ~ modulates Mechanistic
ENFLURANE ~ modulates Mechanistic
FLUNITRAZEPAM ~ modulates Mechanistic
ETOMIDATE ~ modulates Mechanistic
BUTOBARBITAL ? unclear Mechanistic
CLONAZEPAM ~ modulates Mechanistic
ESZOPICLONE ~ modulates Mechanistic
PHENOBARBITAL ? unclear Mechanistic
MEPROBAMATE activates Mechanistic
PRIMIDONE ~ modulates Mechanistic
ETIFOXINE inhibits Mechanistic
FLURAZEPAM ? unclear Mechanistic
TEMAZEPAM ~ modulates Mechanistic
ALPRAZOLAM ~ modulates Mechanistic 12.0 nM (EC50)
OXAZEPAM ~ modulates Mechanistic
SECOBARBITAL ? unclear Mechanistic
LORAZEPAM ~ modulates Mechanistic
PRAZEPAM ~ modulates Mechanistic
HALOTHANE ~ modulates Mechanistic
FLUMAZENIL ~ modulates Mechanistic 0.7943 nM (Ki)
BUTABARBITAL SODIUM ~ modulates Mechanistic
ABP-700 activates Mechanistic
GANAXOLONE ~ modulates Mechanistic
SECOBARBITAL SODIUM ~ modulates Mechanistic
HEXOBARBITAL ? unclear Mechanistic
ZOPICLONE ~ modulates Mechanistic
DARIGABAT activates Mechanistic
COCAINE ? unclear Mechanistic
MEPHOBARBITAL ? unclear Mechanistic
TALBUTAL ~ modulates Mechanistic
ACAMPROSATE CALCIUM ~ modulates Mechanistic

Showing top 40 of 237 agents ranked by evidence tier.

Therapeutic Agent Effect Direction Evidence Tier Potency Source
SERTRALINE HYDROCHLORIDE ? unclear Mechanistic
QUETIAPINE FUMARATE ? unclear Mechanistic
FLIBANSERIN ? unclear Mechanistic
SARIZOTAN HYDROCHLORIDE activates Mechanistic
LISURIDE ? unclear Mechanistic 0.4 nM (Ki)
CLOZAPINE ? unclear Mechanistic
BIFEPRUNOX activates Mechanistic
DU 125530 inhibits Mechanistic
ILOPERIDONE ? unclear Mechanistic
XALIPRODEN activates Mechanistic
BUSPIRONE HYDROCHLORIDE activates Mechanistic
ENSACULIN HYDROCHLORIDE ? unclear Mechanistic
VORTIOXETINE HYDROBROMIDE activates Mechanistic
NORTRIPTYLINE ? unclear Mechanistic
ELTOPRAZINE ? unclear Mechanistic
ARIPIPRAZOLE LAUROXIL activates Mechanistic
METHYSERGIDE ? unclear Mechanistic
TRAZODONE ? unclear Mechanistic
PIROMELATINE ? unclear Mechanistic
ULOTARONT activates Mechanistic
MN-305 ? unclear Mechanistic
CLOMIPRAMINE ? unclear Mechanistic
OXYMETAZOLINE HYDROCHLORIDE ? unclear Mechanistic
BUSPIRONE ? unclear Mechanistic 3.1 nM (Ki)
MILNACIPRAN ? unclear Mechanistic
MONOAMINE OXIDASE INHIBITOR ? unclear Mechanistic
TRIMIPRAMINE ? unclear Mechanistic
MIRTAZAPINE ? unclear Mechanistic
GEPIRONE activates Mechanistic
OPC-14523 ? unclear Mechanistic
BREXPIPRAZOLE activates Mechanistic
ALVERINE inhibits Mechanistic
NALUZOTAN activates Mechanistic
PARDOPRUNOX activates Mechanistic
MAZAPERTINE SUCCINATE ? unclear Mechanistic
METHAMPHETAMINE ? unclear Mechanistic
DOXEPIN HYDROCHLORIDE ? unclear Mechanistic
AMISULPRIDE inhibits Mechanistic
DEXFENFLURAMINE HYDROCHLORIDE activates Mechanistic
NARATRIPTAN ? unclear Mechanistic

Showing top 40 of 260 agents ranked by evidence tier.

Therapeutic Agent Effect Direction Evidence Tier Potency Source
TESOFENSINE inhibits Mechanistic
PHENMETRAZINE ? unclear Mechanistic
VENLAFAXINE ? unclear Mechanistic 1060.0 nM (Kd)
SIBUTRAMINE HYDROCHLORIDE inhibits Mechanistic
DEXMETHYLPHENIDATE inhibits Mechanistic
TRIMIPRAMINE ? unclear Mechanistic
CLOMIPRAMINE ? unclear Mechanistic
GUANADREL SULFATE ? unclear Mechanistic
TAPENTADOL HYDROCHLORIDE inhibits Mechanistic
LISDEXAMFETAMINE DIMESYLATE ? unclear Mechanistic
PROTRIPTYLINE ? unclear Mechanistic
DESVENLAFAXINE SUCCINATE inhibits Mechanistic
ATOMOXETINE HYDROCHLORIDE inhibits Mechanistic
IOBENGUANE I-123 ? unclear Mechanistic
SURONACRINE MALEATE ? unclear Mechanistic
REBOXETINE inhibits Mechanistic 1.1 nM (Ki)
BICIFADINE inhibits Mechanistic
DOXEPIN HYDROCHLORIDE inhibits Mechanistic
LIAFENSINE inhibits Mechanistic
ORPHENADRINE HYDROCHLORIDE inhibits Mechanistic
DULOXETINE HYDROCHLORIDE inhibits Mechanistic
DASOTRALINE inhibits Mechanistic
DESIPRAMINE HYDROCHLORIDE inhibits Mechanistic
METHYLPHENIDATE HYDROCHLORIDE inhibits Mechanistic
AMITIFADINE inhibits Mechanistic
NEFAZODONE ? unclear Mechanistic 360.0 nM (Kd)
AMITIFADINE HYDROCHLORIDE ? unclear Mechanistic
DEXTROAMPHETAMINE SULFATE ? unclear Mechanistic
TYROSINE HYDROXYLASE INHIBITOR ? unclear Mechanistic
NORTRIPTYLINE ? unclear Mechanistic 6.3 nM (Ki)
MAPROTILINE HYDROCHLORIDE inhibits Mechanistic
ST. JOHN'S WORT ? unclear Mechanistic
DEXTROAMPHETAMINE SACCHARATE ? unclear Mechanistic
AMOXAPINE inhibits Mechanistic
PHENDIMETRAZINE inhibits Mechanistic
PHENYLPROPANOLAMINE HYDROCHLORIDE ? unclear Mechanistic
BUPROPION HYDROCHLORIDE inhibits Mechanistic
BETHANIDINE ? unclear Mechanistic
TRAMADOL ? unclear Mechanistic
MILNACIPRAN ? unclear Mechanistic

Showing top 40 of 269 agents ranked by evidence tier.

Therapeutic Agent Effect Direction Evidence Tier Potency Source
CENTANAFADINE inhibits Mechanistic
METHAMPHETAMINE inhibits Mechanistic
VENLAFAXINE HYDROCHLORIDE inhibits Mechanistic
LUMATEPERONE inhibits Mechanistic
TIANEPTINE ? unclear Mechanistic
IMIPRAMINE HYDROCHLORIDE inhibits Mechanistic
ONDANSETRON HYDROCHLORIDE ? unclear Mechanistic
PEGINTERFERON ALFA-2B ? unclear Mechanistic
DEXFENFLURAMINE ? unclear Mechanistic
BUPROPION HYDROCHLORIDE ? unclear Mechanistic
CITALOPRAM inhibits Mechanistic 1.6 nM (Ki)
TRIMIPRAMINE ? unclear Mechanistic
VENLAFAXINE ? unclear Mechanistic 8.9 nM (Kd)
DISULFIRAM ? unclear Mechanistic
CHLORPHENTERMINE HYDROCHLORIDE ? unclear Mechanistic
PROTRIPTYLINE ? unclear Mechanistic
MILNACIPRAN HYDROCHLORIDE inhibits Mechanistic
CLOMIPRAMINE ? unclear Mechanistic 70.0 nM (IC50)
NORTRIPTYLINE ? unclear Mechanistic
DAPOXETINE inhibits Mechanistic
AMITRIPTYLINE HYDROCHLORIDE inhibits Mechanistic
TEDATIOXETINE inhibits Mechanistic
TRAZODONE inhibits Mechanistic
SERTRALINE HYDROCHLORIDE inhibits Mechanistic
EVODIAMINE ? unclear Mechanistic
PSEUDOEPHEDRINE ? unclear Mechanistic
FLUOXETINE HYDROCHLORIDE inhibits Mechanistic
SIBUTRAMINE ? unclear Mechanistic
TRAMADOL ? unclear Mechanistic
VORTIOXETINE HYDROBROMIDE inhibits Mechanistic
BL-1021 ? unclear Mechanistic
DOXEPIN HYDROCHLORIDE ? unclear Mechanistic
DOTHIEPIN inhibits Mechanistic
DEXTROMETHORPHAN POLISTIREX ? unclear Mechanistic
DESIPRAMINE ? unclear Mechanistic
PHENTERMINE RESIN ? unclear Mechanistic
NORTRIPTYLINE HYDROCHLORIDE inhibits Mechanistic
MONOAMINE OXIDASE INHIBITOR ? unclear Mechanistic
MILNACIPRAN ? unclear Mechanistic
RIBAVIRIN ? unclear Mechanistic

Showing top 40 of 224 agents ranked by evidence tier.


Clinical Trials

Recruiting and recently completed trials from ClinicalTrials.gov. Data retrieved 2026-07-03.

NCT07464158 Phase: NA Started: 2026-03-21

The purpose of the study is to investigate and compare the effects of three different versions of a future imaginal writing exercise (worst-case scenario, neutral future scenario, best-case scenario) for individuals with elevated social anxiety symptoms. Participants (estimated N=270) will be recrui...

NCT06162741 Phase: NA Started: 2024-08-19

The VA wants to understand what type of integrative and whole health approaches are helpful for Veterans. The study is comparing two primary care based mental health treatments, a mindfulness class that teaches mindfulness meditation and a problem-solving class that teaches problem-solving skills an...

NCT07682064 Phase: NA Started: 2024-04-27

This study has three primary objectives: 1. To adapt the Spanish version of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP; Barlow et al., 2011, 2019a, 2019b) for delivery in a group format within the Spanish Public Mental Health System for adults diagnosed with emoti...

NCT07681765 Phase: NA Started: 2025-09-12

The goal of this clinical trial is to learn if a psychomotor (a body-oriented therapy) group intervention can be feasibly delivered to a group of young adults (age 18-35) with anxiety symptoms within a higher educational setting. The main questions it aims to answer are: * Is it possible to recrui...

NCT05709002 Phase: NA Started: 2023-10-16

The present investigation aims to address disparities in cigarette use outcomes among Black/African American adults with HIV. The specific aims of this study are: (1) To modify a recently developed, culturally adapted, mobile application for Black smokers by integrating information specifically rele...

NCT07681687 Phase: NA Started: 2026-01-01

A randomized controlled trial to evaluate the effectiveness of Sensory Motor Control training combined with Muscle Energy Technique in reducing pain and improving function, cervical range of motion, proprioception, and kinesiophobia in individuals with chronic mechanical neck pain

NCT07682116 Phase: NA Started: 2026-03-13

This study aims to compare the effects of artificial intelligence-generated feedback and human instructor feedback on learning outcomes in preclinical restorative dentistry education. Third-year dental students performing restorative procedures on simulated teeth received either AI-generated feedbac...

NCT07224165 Phase: NA Started: 2026-06-04

This is a feasibility trial of a digital mental health intervention aimed at adolescents (ages 14-18) with nonsuicidal self-injury and who are not currently engaged in mental health treatment. The study has two arms: a self-guided DMHI and an active control which will involve the delivery of non-int...

NCT07103902 Phase: NA Started: 2026-02-16

The purpose of this study is to examine the acute effects of exercise on cognitive flexibility and symptom reactivity. The main questions it aims to answer are: Does moderate intensity physical activity reduce subjective distress, compulsive urges, and intrusions- and increase cognitive flexibility...

NCT07680192 Phase: NA Started: 2024-01-20

Cardiovascular surgery is associated with high levels of anxiety, uncertainty, and postoperative complications. Educational interventions led by nurses may improve patients' psychological adaptation, self-care abilities, and recovery outcomes. This randomized controlled trial aims to evaluate the e...

NCT06956105 Phase: NA Started: 2025-09-08

Trial title: A Randomized, Double-blind Sham-controlled Clinical Trial to Evaluate The Efficacy of Electrical Vestibular Stimulation (VeNS), Compared to a Sham Control For The Management Of Anxiety in Adolescents - The Modius Calm Adolescent Study The aim of this study: This investigation aims to e...

NCT06633458 Phase: N/A Started: 2024-07-08

The quality of parent-adolescent communication has been found to be associated with adolescent mental health. However, little is known about the association of parent-adolescent communication and adolescent mental health in the context of psychiatry inpatient treatment. This study aims to find out ...

NCT07246798 Phase: N/A Started: 2025-12-20

This prospective single-group study aims to evaluate the effect of preoperative artificial intelligence-based video education on anxiety, anesthesia preference, satisfaction, and knowledge level in patients undergoing arthroscopic lower extremity surgery.

NCT07679321 Phase: N/A Started: 2024-12-01

The goal of this clinical trial is to explore the impact of anxiety/depression on the efficacy of asthma controller medications and to develop a risk prediction model for asthma acute exacerbations in patients with asthma. It will also analyze the association between anxiety/depression severity and ...

NCT06741254 Phase: NA Started: 2024-12-20

Non-stress testing (NST) is used to assess fetal wellbeing and to detect and intervene early in fetuses at risk. NST is an easy to administer, noninvasive, prenatal assessment method used from 32 weeks of gestation to term. High levels of anxiety during the common NST procedure can negatively affect...


Agents Found By Disease-Level Search

Searched directly from “Anxiety Disorders” via ClinicalTrials.gov interventions and Open Targets' disease→drug data — independent of the 7-gene target panel above. This surfaces agents whose mechanism doesn't route through a curated gene (combination therapies, standard-of-care drugs, targets outside the panel).

Not yet run. python -m biomarker_pipeline.run_disease_agent_discovery --disease "..."

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