Disease Overview
Gene targets queried against DGIdb, Open Targets, ChEMBL, PubMed, and Europe PMC. Agents ranked: ● Clinical > ● Mechanistic > ● Correlative.
BDNF
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| TRAMADOL | ? unclear | Mechanistic | DGIdb | |
| FLUTICASONE | ↑ activates | Mechanistic | DGIdb | |
| IONOMYCIN | ? unclear | Mechanistic | DGIdb | |
| MONOAMINE OXIDASE INHIBITOR | ? unclear | Mechanistic | DGIdb | |
| FREUND'S ADJUVANT | ? unclear | Mechanistic | DGIdb | |
| LITHIUM | ? unclear | Mechanistic | DGIdb | |
| ZINC SULFATE ANHYDROUS | ? unclear | Mechanistic | DGIdb | |
| CAPSAICIN | ? unclear | Mechanistic | DGIdb | |
| PROPRANOLOL HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| MARIJUANA | ? unclear | Mechanistic | DGIdb | |
| NORTRIPTYLINE | ? unclear | Mechanistic | DGIdb | |
| BORTEZOMIB | ? unclear | Mechanistic | DGIdb | |
| GLUCAGON (RDNA) | ? unclear | Mechanistic | DGIdb | |
| COLCHICINE | ? unclear | Mechanistic | DGIdb | |
| DOXEPIN HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| DRONABINOL | ? unclear | Mechanistic | DGIdb | |
| TANAPROGET | ↑ activates | Mechanistic | DGIdb | |
| CYCLOOXYGENASE INHIBITOR | ? unclear | Mechanistic | DGIdb | |
| VERTEPORFIN | ? unclear | Mechanistic | DGIdb | |
| ANTIOXIDANT | ? unclear | Mechanistic | DGIdb | |
| DITIOCARB | ? unclear | Mechanistic | DGIdb | |
| APR19 | ↓ inhibits | Mechanistic | DGIdb | |
| DOXORUBICIN HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| OPIATE | ? unclear | Mechanistic | DGIdb | |
| OXIDOPAMINE | ? unclear | Mechanistic | DGIdb | |
| TETRADECANOYLPHORBOL ACETATE | ? unclear | Mechanistic | DGIdb | |
| INSULIN, REGULAR, HUMAN | ? unclear | Mechanistic | DGIdb | |
| PROPYLTHIOURACIL | ? unclear | Mechanistic | DGIdb | |
| TROGLITAZONE | ? unclear | Mechanistic | DGIdb | |
| TYROSINE HYDROXYLASE INHIBITOR | ? unclear | Mechanistic | DGIdb | |
| ALTEPLASE | ? unclear | Mechanistic | DGIdb | |
| MEDICATION | ? unclear | Mechanistic | DGIdb | |
| HALOPERIDOL DECANOATE | ? unclear | Mechanistic | DGIdb | |
| ASOPRISNIL | ↓ inhibits | Mechanistic | DGIdb | |
| ANALGESIC AGENT | ? unclear | Mechanistic | DGIdb | |
| TCDD | ? unclear | Mechanistic | DGIdb | |
| THERAPEUTIC GONADOTROPIN | ? unclear | Mechanistic | DGIdb | |
| METHADONE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| RECOMBINANT TRANSFORMING GROWTH FACTOR | ? unclear | Mechanistic | DGIdb | |
| ONAPRISTONE | ↓ inhibits | Mechanistic | DGIdb |
Showing top 40 of 126 agents ranked by evidence tier.
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| ROSIGLITAZONE | ? unclear | Mechanistic | DGIdb | |
| ACIVICIN | ↓ inhibits | Mechanistic | DGIdb | |
| MEDICATION | ? unclear | Mechanistic | DGIdb | |
| GGSTOP | ↓ inhibits | Mechanistic | DGIdb | |
| ANTIDEPRESSANT AGENT | ? unclear | Mechanistic | DGIdb | |
| IRX-2 | ? unclear | Mechanistic | DGIdb | |
| ANTISERUM | ? unclear | Mechanistic | DGIdb | |
| NALOXONE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| CHEMBL5286255 | ↓ inhibits | Mechanistic | 0.7 nM (Ki) | ChEMBL |
GABRA1
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| CHLORDIAZEPOXIDE | ~ modulates | Mechanistic | DGIdb | |
| ETIFOXINE | ↓ inhibits | Mechanistic | DGIdb | |
| DIAZEPAM | ~ modulates | Mechanistic | 36.0 nM (Kd) | DGIdb |
| METHARBITAL | ~ modulates | Mechanistic | DGIdb | |
| L838417 | ~ modulates | Mechanistic | DGIdb | |
| GANAXOLONE | ~ modulates | Mechanistic | DGIdb | |
| THIAMYLAL SODIUM | ~ modulates | Mechanistic | DGIdb | |
| EVT 201 | ? unclear | Mechanistic | DGIdb | |
| ADINAZOLAM | ? unclear | Mechanistic | DGIdb | |
| ZK-93423 | ? unclear | Mechanistic | DGIdb | |
| AMOBARBITAL | ? unclear | Mechanistic | DGIdb | |
| ETHCHLORVYNOL | ~ modulates | Mechanistic | DGIdb | |
| SECOBARBITAL SODIUM | ~ modulates | Mechanistic | DGIdb | |
| MEPHOBARBITAL | ? unclear | Mechanistic | DGIdb | |
| ZOLPIDEM TARTRATE | ~ modulates | Mechanistic | DGIdb | |
| METHAQUALONE | ~ modulates | Mechanistic | DGIdb | |
| TOPIRAMATE | ~ modulates | Mechanistic | DGIdb | |
| PAGOCLONE | ~ modulates | Mechanistic | DGIdb | |
| THIOCOLCHICOSIDE | ? unclear | Mechanistic | DGIdb | |
| [3H]AZIETOMIDATE | ? unclear | Mechanistic | DGIdb | |
| PENTOBARBITAL SODIUM | ~ modulates | Mechanistic | DGIdb | |
| MIDAZOLAM HYDROCHLORIDE | ~ modulates | Mechanistic | DGIdb | |
| TRIAZOLAM | ~ modulates | Mechanistic | 1.0 nM (Kd) | DGIdb |
| BARBITURATE | ? unclear | Mechanistic | DGIdb | |
| LORAZEPAM | ~ modulates | Mechanistic | DGIdb | |
| BUTOBARBITAL | ? unclear | Mechanistic | DGIdb | |
| TETRAHYDRODEOXYCORTICOSTERONE | ~ modulates | Mechanistic | DGIdb | |
| CLOTIAZEPAM | ~ modulates | Mechanistic | DGIdb | |
| MEPROBAMATE | ↑ activates | Mechanistic | DGIdb | |
| [3H]CGS8216 | ~ modulates | Mechanistic | DGIdb | |
| PROPOFOL | ~ modulates | Mechanistic | DGIdb | |
| CLOBAZAM | ~ modulates | Mechanistic | DGIdb | |
| SEVOFLURANE | ~ modulates | Mechanistic | DGIdb | |
| METHOXYFLURANE | ~ modulates | Mechanistic | DGIdb | |
| LOREDIPLON | ~ modulates | Mechanistic | DGIdb | |
| CIPEPOFOL | ↑ activates | Mechanistic | DGIdb | |
| INDIPLON | ~ modulates | Mechanistic | DGIdb | |
| PHENOBARBITAL | ? unclear | Mechanistic | DGIdb | |
| PRAZEPAM | ~ modulates | Mechanistic | DGIdb | |
| CLORAZEPATE | ? unclear | Mechanistic | DGIdb |
Showing top 40 of 303 agents ranked by evidence tier.
GABRA2
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| METHARBITAL | ~ modulates | Mechanistic | DGIdb | |
| OCINAPLON | ? unclear | Mechanistic | DGIdb | |
| THIOPENTAL | ? unclear | Mechanistic | DGIdb | |
| DIAZEPAM | ~ modulates | Mechanistic | 17.0 nM (Ki) | DGIdb |
| PENTOBARBITAL SODIUM | ~ modulates | Mechanistic | DGIdb | |
| FLUDIAZEPAM | ? unclear | Mechanistic | DGIdb | |
| ADINAZOLAM | ? unclear | Mechanistic | DGIdb | |
| ADIPIPLON | ↑ activates | Mechanistic | DGIdb | |
| TOPIRAMATE | ~ modulates | Mechanistic | DGIdb | |
| CLORAZEPATE DIPOTASSIUM | ~ modulates | Mechanistic | DGIdb | |
| ENFLURANE | ~ modulates | Mechanistic | DGIdb | |
| FLUNITRAZEPAM | ~ modulates | Mechanistic | DGIdb | |
| ETOMIDATE | ~ modulates | Mechanistic | DGIdb | |
| BUTOBARBITAL | ? unclear | Mechanistic | DGIdb | |
| CLONAZEPAM | ~ modulates | Mechanistic | DGIdb | |
| ESZOPICLONE | ~ modulates | Mechanistic | DGIdb | |
| PHENOBARBITAL | ? unclear | Mechanistic | DGIdb | |
| MEPROBAMATE | ↑ activates | Mechanistic | DGIdb | |
| PRIMIDONE | ~ modulates | Mechanistic | DGIdb | |
| ETIFOXINE | ↓ inhibits | Mechanistic | DGIdb | |
| FLURAZEPAM | ? unclear | Mechanistic | DGIdb | |
| TEMAZEPAM | ~ modulates | Mechanistic | DGIdb | |
| ALPRAZOLAM | ~ modulates | Mechanistic | 12.0 nM (EC50) | DGIdb |
| OXAZEPAM | ~ modulates | Mechanistic | DGIdb | |
| SECOBARBITAL | ? unclear | Mechanistic | DGIdb | |
| LORAZEPAM | ~ modulates | Mechanistic | DGIdb | |
| PRAZEPAM | ~ modulates | Mechanistic | DGIdb | |
| HALOTHANE | ~ modulates | Mechanistic | DGIdb | |
| FLUMAZENIL | ~ modulates | Mechanistic | 0.7943 nM (Ki) | DGIdb |
| BUTABARBITAL SODIUM | ~ modulates | Mechanistic | DGIdb | |
| ABP-700 | ↑ activates | Mechanistic | DGIdb | |
| GANAXOLONE | ~ modulates | Mechanistic | DGIdb | |
| SECOBARBITAL SODIUM | ~ modulates | Mechanistic | DGIdb | |
| HEXOBARBITAL | ? unclear | Mechanistic | DGIdb | |
| ZOPICLONE | ~ modulates | Mechanistic | DGIdb | |
| DARIGABAT | ↑ activates | Mechanistic | DGIdb | |
| COCAINE | ? unclear | Mechanistic | DGIdb | |
| MEPHOBARBITAL | ? unclear | Mechanistic | DGIdb | |
| TALBUTAL | ~ modulates | Mechanistic | DGIdb | |
| ACAMPROSATE CALCIUM | ~ modulates | Mechanistic | DGIdb |
Showing top 40 of 237 agents ranked by evidence tier.
HTR1A
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| SERTRALINE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| QUETIAPINE FUMARATE | ? unclear | Mechanistic | DGIdb | |
| FLIBANSERIN | ? unclear | Mechanistic | DGIdb | |
| SARIZOTAN HYDROCHLORIDE | ↑ activates | Mechanistic | DGIdb | |
| LISURIDE | ? unclear | Mechanistic | 0.4 nM (Ki) | DGIdb |
| CLOZAPINE | ? unclear | Mechanistic | DGIdb | |
| BIFEPRUNOX | ↑ activates | Mechanistic | DGIdb | |
| DU 125530 | ↓ inhibits | Mechanistic | DGIdb | |
| ILOPERIDONE | ? unclear | Mechanistic | DGIdb | |
| XALIPRODEN | ↑ activates | Mechanistic | DGIdb | |
| BUSPIRONE HYDROCHLORIDE | ↑ activates | Mechanistic | DGIdb | |
| ENSACULIN HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| VORTIOXETINE HYDROBROMIDE | ↑ activates | Mechanistic | DGIdb | |
| NORTRIPTYLINE | ? unclear | Mechanistic | DGIdb | |
| ELTOPRAZINE | ? unclear | Mechanistic | DGIdb | |
| ARIPIPRAZOLE LAUROXIL | ↑ activates | Mechanistic | DGIdb | |
| METHYSERGIDE | ? unclear | Mechanistic | DGIdb | |
| TRAZODONE | ? unclear | Mechanistic | DGIdb | |
| PIROMELATINE | ? unclear | Mechanistic | DGIdb | |
| ULOTARONT | ↑ activates | Mechanistic | DGIdb | |
| MN-305 | ? unclear | Mechanistic | DGIdb | |
| CLOMIPRAMINE | ? unclear | Mechanistic | DGIdb | |
| OXYMETAZOLINE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| BUSPIRONE | ? unclear | Mechanistic | 3.1 nM (Ki) | DGIdb |
| MILNACIPRAN | ? unclear | Mechanistic | DGIdb | |
| MONOAMINE OXIDASE INHIBITOR | ? unclear | Mechanistic | DGIdb | |
| TRIMIPRAMINE | ? unclear | Mechanistic | DGIdb | |
| MIRTAZAPINE | ? unclear | Mechanistic | DGIdb | |
| GEPIRONE | ↑ activates | Mechanistic | DGIdb | |
| OPC-14523 | ? unclear | Mechanistic | DGIdb | |
| BREXPIPRAZOLE | ↑ activates | Mechanistic | DGIdb | |
| ALVERINE | ↓ inhibits | Mechanistic | DGIdb | |
| NALUZOTAN | ↑ activates | Mechanistic | DGIdb | |
| PARDOPRUNOX | ↑ activates | Mechanistic | DGIdb | |
| MAZAPERTINE SUCCINATE | ? unclear | Mechanistic | DGIdb | |
| METHAMPHETAMINE | ? unclear | Mechanistic | DGIdb | |
| DOXEPIN HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| AMISULPRIDE | ↓ inhibits | Mechanistic | DGIdb | |
| DEXFENFLURAMINE HYDROCHLORIDE | ↑ activates | Mechanistic | DGIdb | |
| NARATRIPTAN | ? unclear | Mechanistic | DGIdb |
Showing top 40 of 260 agents ranked by evidence tier.
SLC6A2
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| TESOFENSINE | ↓ inhibits | Mechanistic | DGIdb | |
| PHENMETRAZINE | ? unclear | Mechanistic | DGIdb | |
| VENLAFAXINE | ? unclear | Mechanistic | 1060.0 nM (Kd) | DGIdb |
| SIBUTRAMINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| DEXMETHYLPHENIDATE | ↓ inhibits | Mechanistic | DGIdb | |
| TRIMIPRAMINE | ? unclear | Mechanistic | DGIdb | |
| CLOMIPRAMINE | ? unclear | Mechanistic | DGIdb | |
| GUANADREL SULFATE | ? unclear | Mechanistic | DGIdb | |
| TAPENTADOL HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| LISDEXAMFETAMINE DIMESYLATE | ? unclear | Mechanistic | DGIdb | |
| PROTRIPTYLINE | ? unclear | Mechanistic | DGIdb | |
| DESVENLAFAXINE SUCCINATE | ↓ inhibits | Mechanistic | DGIdb | |
| ATOMOXETINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| IOBENGUANE I-123 | ? unclear | Mechanistic | DGIdb | |
| SURONACRINE MALEATE | ? unclear | Mechanistic | DGIdb | |
| REBOXETINE | ↓ inhibits | Mechanistic | 1.1 nM (Ki) | DGIdb |
| BICIFADINE | ↓ inhibits | Mechanistic | DGIdb | |
| DOXEPIN HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| LIAFENSINE | ↓ inhibits | Mechanistic | DGIdb | |
| ORPHENADRINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| DULOXETINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| DASOTRALINE | ↓ inhibits | Mechanistic | DGIdb | |
| DESIPRAMINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| METHYLPHENIDATE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| AMITIFADINE | ↓ inhibits | Mechanistic | DGIdb | |
| NEFAZODONE | ? unclear | Mechanistic | 360.0 nM (Kd) | DGIdb |
| AMITIFADINE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| DEXTROAMPHETAMINE SULFATE | ? unclear | Mechanistic | DGIdb | |
| TYROSINE HYDROXYLASE INHIBITOR | ? unclear | Mechanistic | DGIdb | |
| NORTRIPTYLINE | ? unclear | Mechanistic | 6.3 nM (Ki) | DGIdb |
| MAPROTILINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| ST. JOHN'S WORT | ? unclear | Mechanistic | DGIdb | |
| DEXTROAMPHETAMINE SACCHARATE | ? unclear | Mechanistic | DGIdb | |
| AMOXAPINE | ↓ inhibits | Mechanistic | DGIdb | |
| PHENDIMETRAZINE | ↓ inhibits | Mechanistic | DGIdb | |
| PHENYLPROPANOLAMINE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| BUPROPION HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| BETHANIDINE | ? unclear | Mechanistic | DGIdb | |
| TRAMADOL | ? unclear | Mechanistic | DGIdb | |
| MILNACIPRAN | ? unclear | Mechanistic | DGIdb |
Showing top 40 of 269 agents ranked by evidence tier.
SLC6A4
| Therapeutic Agent | Effect Direction | Evidence Tier | Potency | Source |
|---|---|---|---|---|
| CENTANAFADINE | ↓ inhibits | Mechanistic | DGIdb | |
| METHAMPHETAMINE | ↓ inhibits | Mechanistic | DGIdb | |
| VENLAFAXINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| LUMATEPERONE | ↓ inhibits | Mechanistic | DGIdb | |
| TIANEPTINE | ? unclear | Mechanistic | DGIdb | |
| IMIPRAMINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| ONDANSETRON HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| PEGINTERFERON ALFA-2B | ? unclear | Mechanistic | DGIdb | |
| DEXFENFLURAMINE | ? unclear | Mechanistic | DGIdb | |
| BUPROPION HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| CITALOPRAM | ↓ inhibits | Mechanistic | 1.6 nM (Ki) | DGIdb |
| TRIMIPRAMINE | ? unclear | Mechanistic | DGIdb | |
| VENLAFAXINE | ? unclear | Mechanistic | 8.9 nM (Kd) | DGIdb |
| DISULFIRAM | ? unclear | Mechanistic | DGIdb | |
| CHLORPHENTERMINE HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| PROTRIPTYLINE | ? unclear | Mechanistic | DGIdb | |
| MILNACIPRAN HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| CLOMIPRAMINE | ? unclear | Mechanistic | 70.0 nM (IC50) | DGIdb |
| NORTRIPTYLINE | ? unclear | Mechanistic | DGIdb | |
| DAPOXETINE | ↓ inhibits | Mechanistic | DGIdb | |
| AMITRIPTYLINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| TEDATIOXETINE | ↓ inhibits | Mechanistic | DGIdb | |
| TRAZODONE | ↓ inhibits | Mechanistic | DGIdb | |
| SERTRALINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| EVODIAMINE | ? unclear | Mechanistic | DGIdb | |
| PSEUDOEPHEDRINE | ? unclear | Mechanistic | DGIdb | |
| FLUOXETINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| SIBUTRAMINE | ? unclear | Mechanistic | DGIdb | |
| TRAMADOL | ? unclear | Mechanistic | DGIdb | |
| VORTIOXETINE HYDROBROMIDE | ↓ inhibits | Mechanistic | DGIdb | |
| BL-1021 | ? unclear | Mechanistic | DGIdb | |
| DOXEPIN HYDROCHLORIDE | ? unclear | Mechanistic | DGIdb | |
| DOTHIEPIN | ↓ inhibits | Mechanistic | DGIdb | |
| DEXTROMETHORPHAN POLISTIREX | ? unclear | Mechanistic | DGIdb | |
| DESIPRAMINE | ? unclear | Mechanistic | DGIdb | |
| PHENTERMINE RESIN | ? unclear | Mechanistic | DGIdb | |
| NORTRIPTYLINE HYDROCHLORIDE | ↓ inhibits | Mechanistic | DGIdb | |
| MONOAMINE OXIDASE INHIBITOR | ? unclear | Mechanistic | DGIdb | |
| MILNACIPRAN | ? unclear | Mechanistic | DGIdb | |
| RIBAVIRIN | ? unclear | Mechanistic | DGIdb |
Showing top 40 of 224 agents ranked by evidence tier.
Recruiting and recently completed trials from ClinicalTrials.gov. Data retrieved 2026-07-03.
The purpose of the study is to investigate and compare the effects of three different versions of a future imaginal writing exercise (worst-case scenario, neutral future scenario, best-case scenario) for individuals with elevated social anxiety symptoms. Participants (estimated N=270) will be recrui...
The VA wants to understand what type of integrative and whole health approaches are helpful for Veterans. The study is comparing two primary care based mental health treatments, a mindfulness class that teaches mindfulness meditation and a problem-solving class that teaches problem-solving skills an...
This study has three primary objectives: 1. To adapt the Spanish version of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP; Barlow et al., 2011, 2019a, 2019b) for delivery in a group format within the Spanish Public Mental Health System for adults diagnosed with emoti...
The goal of this clinical trial is to learn if a psychomotor (a body-oriented therapy) group intervention can be feasibly delivered to a group of young adults (age 18-35) with anxiety symptoms within a higher educational setting. The main questions it aims to answer are: * Is it possible to recrui...
The present investigation aims to address disparities in cigarette use outcomes among Black/African American adults with HIV. The specific aims of this study are: (1) To modify a recently developed, culturally adapted, mobile application for Black smokers by integrating information specifically rele...
A randomized controlled trial to evaluate the effectiveness of Sensory Motor Control training combined with Muscle Energy Technique in reducing pain and improving function, cervical range of motion, proprioception, and kinesiophobia in individuals with chronic mechanical neck pain
This study aims to compare the effects of artificial intelligence-generated feedback and human instructor feedback on learning outcomes in preclinical restorative dentistry education. Third-year dental students performing restorative procedures on simulated teeth received either AI-generated feedbac...
This is a feasibility trial of a digital mental health intervention aimed at adolescents (ages 14-18) with nonsuicidal self-injury and who are not currently engaged in mental health treatment. The study has two arms: a self-guided DMHI and an active control which will involve the delivery of non-int...
The purpose of this study is to examine the acute effects of exercise on cognitive flexibility and symptom reactivity. The main questions it aims to answer are: Does moderate intensity physical activity reduce subjective distress, compulsive urges, and intrusions- and increase cognitive flexibility...
Cardiovascular surgery is associated with high levels of anxiety, uncertainty, and postoperative complications. Educational interventions led by nurses may improve patients' psychological adaptation, self-care abilities, and recovery outcomes. This randomized controlled trial aims to evaluate the e...
Trial title: A Randomized, Double-blind Sham-controlled Clinical Trial to Evaluate The Efficacy of Electrical Vestibular Stimulation (VeNS), Compared to a Sham Control For The Management Of Anxiety in Adolescents - The Modius Calm Adolescent Study The aim of this study: This investigation aims to e...
The quality of parent-adolescent communication has been found to be associated with adolescent mental health. However, little is known about the association of parent-adolescent communication and adolescent mental health in the context of psychiatry inpatient treatment. This study aims to find out ...
This prospective single-group study aims to evaluate the effect of preoperative artificial intelligence-based video education on anxiety, anesthesia preference, satisfaction, and knowledge level in patients undergoing arthroscopic lower extremity surgery.
The goal of this clinical trial is to explore the impact of anxiety/depression on the efficacy of asthma controller medications and to develop a risk prediction model for asthma acute exacerbations in patients with asthma. It will also analyze the association between anxiety/depression severity and ...
Non-stress testing (NST) is used to assess fetal wellbeing and to detect and intervene early in fetuses at risk. NST is an easy to administer, noninvasive, prenatal assessment method used from 32 weeks of gestation to term. High levels of anxiety during the common NST procedure can negatively affect...
Searched directly from “Anxiety Disorders” via ClinicalTrials.gov interventions and Open Targets' disease→drug data — independent of the 7-gene target panel above. This surfaces agents whose mechanism doesn't route through a curated gene (combination therapies, standard-of-care drugs, targets outside the panel).
Not yet run. python -m biomarker_pipeline.run_disease_agent_discovery --disease "..."